Suppressive Effects of Genistein on Oxidative Stress and NFkB Activation in RAW 264.7 Macrophages(Food & Nutrition Science)
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概要
- 論文の詳細を見る
This study was designed to investigate whether genistein may ameliorate oxidative stress and nuclear factor kB (NFkB) activation in the lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophage cell line. Treatment of RAW 264.7 cells with genistein significantly reduced lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production in a dose-dependent manner with an IC_<50> of 69.4 μM. Genistein at 50 μM and 100 μM concentrations reduced thiobarbituric acid-reactive substances (TBARS) accumulation, increasing the GSH level and antioxidant enzyme activities, such as superoxide dismutase (SOD) and catalase. The specific DNA-binding activities of nuclear factor kB (NFkB) on nuclear extracts from 50 μM and 100 μM genistein treatments were significanly suppressed. These results suggest that genistein has mild antioxidant activity to suppress intracellular oxidative stress and NFkB activation.
- 社団法人日本農芸化学会の論文
- 2003-09-23
著者
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Song Youngsun
School Of Food And Life Science Food Science Institute And Biohealth Product Research Center Inje Un
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Song Youngsun
School Of Food And Life Science And Biohealth Product Research Center Inje University
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CHO Chungwon
School of Biomedical and Biotechnology, Inje University
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CHOI Chunyeon
School of Food and Life Science, Food Science Institute and Biohealth Product Research Center, Inje
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CHO Hyeyeon
School of Food and Life Science, Food Science Institute and Biohealth Product Research Center, Inje
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PARK Jiyoung
School of Food and Life Science, Food Science Institute and Biohealth Product Research Center, Inje
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Cho Hyeyeon
School Of Food And Life Science Food Science Institute And Biohealth Product Research Center Inje Un
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Park Jiyoung
School Of Food And Life Science Food Science Institute And Biohealth Product Research Center Inje Un
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Cho Chungwon
School Of Biomedical And Biotechnology Inje University
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Choi Chunyeon
School Of Food And Life Science Food Science Institute And Biohealth Product Research Center Inje Un
関連論文
- Attenuating Effect of Chlorella Supplementation on Oxidative Stress and NFκB Activation in Peritoneal Macrophages and Liver of C57BL/6 Mice Fed on an Atherogenic Diet(Food & Nutrition Science)
- Suppressive Effects of Genistein on Oxidative Stress and NFkB Activation in RAW 264.7 Macrophages(Food & Nutrition Science)