Stimulation by Histamine of TPA-dependent Hepatocyte Growth Factor Production in Promyelocytic Leukemia HL-60 Cells

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概要

• 論文の詳細を見る

• Hepatocyte growth factor (HGF) is most likely a physiological hepatotrophic factor that triggers regeneration of the injured liver. Histamine may also be important in the pathophysiology of the injured liver. Previously we showed that histamine production was increased in liver macrophages of mice injected with CCl_4,a well-known hepatotoxin. Therefore, it is likely that the biological actions of histamine in repairing processes of the injured liver are mediated by HGF. This study was aimed at examining the effects of histamine on production of HGF using, as a model, the human promyelocytic leukemia cells, HL-60. 12-o-Tetradecanoylphorbol-13-acetate (TPA) markedly stimulated HGF production and release from the cells ; the maximal amount of HGF was released at a concentration of 3 ng/ml of TPA. Histamine significantly stimulated the TPA-induced HGF production and release in these cells, depending on incubation time and its dose. These actions of histamine were abrogated by a H2 receptor antagonist, ranitidine.

• 社団法人日本農芸化学会の論文
• 1998-07-23

著者

• Nakano Kiwao

  Nagoya University Bio-science Center

• Nakamura T

  Shinshu Univ. School Of Medicine Matsumoto Jpn

• Nakano K

  Shinshu Univ. Nagano‐ken Jpn

• Matsumoto Kunio

  Division Of Biochemistry Biomedical Research Center Osaka University Medical School

• Nakamura Toshikazu

  Division Of Biochemistry Biomedical Research Center Omaha University Medical School

• SUZUKI Mitsuru

  Nagoya University Bioscience Center

• Matsumoto Kunio

  Division Of Biochemistry Biomedical Research Center Osaka University Medical Center

• Matsumoto Kunio

  Division Of Bichemistry Biomedical Research Center Osaka University Medical School

• Nakamura Toshikazu

  Division Of Bichemistry Biomedical Research Center Osaka University Medical School

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