Decrease in the Levels of NGF and BDNF in Brains of Mice Fed a Tryptophan-Deficient Diet
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概要
- 論文の詳細を見る
The roles of dietary tryptophan (Trp) were evaluated in regulation of production of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin (NT)-3 in the various brain regions in ddY mice. Feeding the mice a Trp-deficient diet for 2 weeks significantly decreased in the hippocampal level of NGF but not those of BDNF and NT-3,as compared with feeding an adequate Trp diet. The mice fed excess Trp did not have different levels of any of these neurotrophins than in the mice fed an adequate Trp diet. The levels of BDNF in the cerebral cortex were also significantly lower in the mice fed on a Trpdeficient diet, while the levels of NGF and NT-3 in the region were not modulated upon feeding of the diet. The dietary Trp level had no significant effect on the levels of NGF, BDNF, or NT-3 in the entorhinal cortex nor septum of the mice. These results demonstrate that the brain levels of NGF and BDNF are dependent on the dietary content of tryptophan.
- 社団法人日本農芸化学会の論文
- 1999-02-23
著者
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Nakano Kiwao
Nagoya University Graduate School of Agriculture
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Nakano Kiwao
Nagoya University Bioscience Center
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Nakano Kiwao
Nagoya University Bio-science Center
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Semba Ritsuko
Department of Perinatology, Institute for Developmental Research, Human Service Center
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Semba R
Human Serv. Center Aichi Jpn
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Semba Ritsuko
Department Of Perinatology Institute For Developmental Research Human Service Center
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LEE DongRyulu
Nagoya University Bioscience Center
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KONDO Hiromichi
Department of Home Economics, Kinjo University
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GOTO Schunko
Department of Home Economics, Kinjo University
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Goto Schunko
Department Of Home Economics Kinjo University
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Kondo Hiromichi
Department Of Home Economics Kinjo University
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Dong-Ryulu Lee
Nagoya University Bioscience Center
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- Decrease in the Levels of NGF and BDNF in Brains of Mice Fed a Tryptophan-Deficient Diet
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