Biological Activity of Dihydrotanshinone I : Effect on Apoptosis

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概要

• 論文の詳細を見る

• Recently, we have found for the first time that dihydrotanshinone I, isolated from Salvia miltiorrhiza, exhibited cytotoxicity against various tumor cell lines. To investigate whether the mechanism underlying dihydrotanshinone I toxicity involved apoptosis in cancer cell lines, we examined cell growth arrest and cell death by flow cytometric analysis and DNA fragmentation assay. Dihydrotanshinone I induced cell growth arrest during the S phase and subsequently, apoptosis, following its application to K562/ADR cells, whereas cryptotanshinone did not have these effects. These results suggest that the mode of action of dihydrotanshinone I involves apoptotic pathways that are different from those involved in cryptotanshinone toxicity.

• 社団法人日本生物工学会の論文
• 2000-03-25

著者

• Lee Sang-han

  Division Of Medical Oncology Columbia University:samsung Biomedical Research Institute Sung Kyun Kwa

• LEE Dong-Sun

  Department of Microbiology, College of Natural Science, Kyungpook National University

• Lee Dong-sun

  Department Of Microbiology College Of Natural Science Kyungpook National University:biophysical Chem

• Lee Dong-sun

  Department Of Chemistry Seoul Women's University

関連論文

• Inhibition of DNA Topoisomerase I by Dihydrotanshinone I, Components of a Medicinal Herb Salvia miltiorrhiza Bunge
• Biological Activity of Dihydrotanshinone I : Effect on Apoptosis
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