Industrial Application of Fuzzy Control to Large-Scale Recombinant Vitamin B_2 Production
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概要
- 論文の詳細を見る
A fuzzy control system featuring the identification of culture phases by fuzzy logic was applied to the largescale recombinant vitamin B_2(VB_2)production at the Fukuroi factory of Nippon Roche, Fukuroi. Prior to actual operation, the knowledge base for fuzzy control was tuned and verified by a simulation system. Only four rules, formulated as IF〜THEN instructions and membership functions for state variables, are employed to control the feed rate and pH of the fed-batch culture. By applying fuzzy control, total VB_2 production and VB_2 yield was increased by 6-16% and 4-11% compared with conventional control, respectively. Operating stability was also improved. The large-scale fermentor used for VB_2 production has been successfully operated under the control of the fuzzy system for more than 2 years.
- 社団法人日本生物工学会の論文
- 1999-03-25
著者
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Horiuchi Jun-ichi
Department of Biotechnology and Environmental Chemistry, Kitami Institute of Technology
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Horiuchi Jun-ichi
Department Of Biotechnology And Environmental Chemistry Kitami Institute Of Technology
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Horiuchi Jun-ichi
Department Of Chemical System Engineering Kitami Institute Of Technology
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HIRAGA KOHKI
Fukuroi Factory, Nippon Roche K.K.
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Hiraga Kohki
Fukuroi Factory Nippon Roche K.k.
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