普通食あるいは高脂肪食で飼育されたラットの内臓脂肪重量, 安静時代謝および骨格筋の酵素活性

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The first purpose of this study was to examine whether differences existed in high-fat diet-induced changes in metabolic properties between the soleus and plantaris muscles of the rat. The second purpose was to compare the relationships among visceral adipose tissue weight, whole body metabolism estimated from respiratory gas exchange parameters, and enzyme activities of the skeletal muscles in normal diet(N)group and high-fat diet(HF)group. N and HF groups were given commercial chow containing 12.8 % fat and the high-fat diet with 64.6% fat, respectively, for 4 weeks. Epididymal and retroperitoneal fat pad weights were significantly heavier in HF group than in N group although no significant difference existed in body weights between the two groups. Respiratory exchange ratio was significantly lower in HF group as compared with N group, indicating that relative contribution of fat to total energy consumption was larger in the former. 3-hydroxyacyl-CoA dehydrogenase, malate dehydrogenase and citrate synthase activities of the soleus muscle was significantly higher in HF group than in N group while those of the plantaris muscle did not differ between the two groups. Significant correlations existed between the visceral adipose tissue weights and oxidative enzyme activities, not in HF group, but in N group. The results suggest that HF preferentially augments oxidative enzyme activity of the soleus muscles in the rat. The results also suggest that oxidative capacity of the soleus muscle plays an important role in suppressing visceral fat weight gain in N group.
日本運動生理学会の論文
1999-07-30

普通食あるいは高脂肪食で飼育されたラットの内臓脂肪重量, 安静時代謝および骨格筋の酵素活性

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