ラット骨格筋のミオシンLight Chainと酵素活性の発育に伴なう変化について

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Postnatal changes of myosin light chain patterns and enzyme activities were examined in the fast extensor digitorum longus and slow soleus muscles of Wistar strain rats aged 5, 10 and 20 weeks. Sex differences in each parameter were also studied. The results were summarized as follows: 1) The extensor digitorum longus muscle contained mostly the fast light chains (fLC1, fLC2, fLC3). However, small amounts of the slow light chains (sLC1, sLC2) were also found. There were no postnatal changes in myosin light chain patterns in the extensor digitorum longus muscle. 2) The soleus muscle contained slow and fast light chains (sLC1, sLC2, fLC1, fLC2, fLC3)in 5 weeks of age, slow light chains being more predominant than fast light chains. There were an increase in the percentage of slow light chains and a concomitant decrease in the percentage of fast light chains with age. FLC3 which was found at 5 weeks of age did not be detected in the soleus muscle from the 20-week-old rat. 3)PFK activity decreased significantly with age in the soleus muscle, whereas there was no postnatal changes in PFK activity in the extensor digitorum longus muscle. 4) There was a significant increase in SDH activity during growth in both the extensor digitorum longus and soleus muscles with the exception of the extensor digitorum longus muscle from the male rat. 5) The enzyme activity ratio (PFK/SDH) significantly decreased with age in all muscles with an exception of the extensor digitolum longus muscle from the male rat. 6) In the soleus muscle an increase in the relative amount of slow type myosin light chains and a decrease in the enzyme activity ratio (PFK/SDH) occurred coincidentally during postnatal growth. 7) In most cases no significant sex differences existed in myosin light chain pattern and enzyme activity examined.
1986-06-01

ラット骨格筋のミオシンLight Chainと酵素活性の発育に伴なう変化について

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