Serum Uric Acid Level Increases in Proportion to the Severity of Pulmonary Thromboembolism
スポンサーリンク
概要
- 論文の詳細を見る
Serum uric acid (UA) has been proposed as a marker for impaired oxidative metabolism and the present study investigated whether serum UA level increases in proportion to the severity of pulmonary thromhoembolism (PTE) in 193 patients. Serum UA was repeatedly measured after treatment of PIE in 76 patients. Right heart catheterization was performed in a subgroup of patients (n=104). Serum UA on admission was significantly elevated in patients with acute PTE (6.2±2.3 mg/dl) and those with chronic PTE (7.0±2.1 mg/dl) compared with age-matched controls (4.5±0.9 mg/ml). In particular, serum UA was markedly higher in the 27 patients who died during hospitalization than in the remaining survivors (8.3±2.2 vs 6.5±2.2mg/dl, p<0.001). In acute PTE, serum UA negatively correlated with cardiac output, but not significantly with mean pulmonary arterial pressure. In chronic PTE, serum UA negatively correlated with cardiac output and positively correlated with mean pulmonary arterial pressure. Serum UA significantly decreased from 6.7±2.0 to 5.8±1.9 mg/dl with treatment, associated with an increase in cardiac output and in PaO_2. Serum UA increases in proportion to the severity of PTE, and thereby may serve as a potential indicator of the efficacy of treatment of PTE.
- 社団法人日本循環器学会の論文
- 2002-05-20
著者
-
NAGAYA Noritoshi
Research Institute National Cardiovascular Center
-
Shimizu Yoshito
Mazda Hospital
-
Uematsu Masaaki
Osaka Seamen's Insurance Hospital
-
KYOTANI Shingo
Division of Cardiology, National Cardiovascular Center
-
NAKANISHI Norifumi
Division of Cardiology, National Cardiovascular Center
-
NAGAYA Noritoshi
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center
-
Nakanishi Norifumi
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
-
Satoh Toru
Division of Cardiology Department of Medicine, Keio University School of Medicine
-
Miyatake Kunio
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center
-
MINATOYA Kenji
National Cardiovascular Center
-
Miyatake Kunio
Hiroshima General Hospital
-
Sakamaki Fumio
Division Of Cardiology National Cardiovascular Center
-
Sakamaki Fumio
National Cardiovascular Center
-
Sakamaki Fumio
Division Of Cardiology And Pulmonary Circulation Department Of Medicine National Cardiovascular Cent
-
Kyotani Shingo
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
-
Shimizu Yoshito
Division of Cardiology, Department of Medicine, National Cardiovascular Center
-
Uematsu Masaaki
Division of Cardiology, Department of Medicine, National Cardiovascular Center
-
Satoh Toru
Division Of Cardiology Department Of Medicine National Cardiovascular Center
-
Kyotani Shingo
Department Of Cardiology National Cardiovascular Medicine
-
Nakanishi Norifumi
Department Of Cardiology National Cardiovascular Medicine
-
Uematsu Masaaki
Cardiovascular Division Kansai Rosai Hospital
-
Kusumoto Miyako
Cardiac Division National Cardiovascular Center
-
Nagaya Noritoshi
Department Of Regenerative Medicine And Tissue Engineering National Cardiovascular Center Research I
-
Miyatake Kunio
Division Of Cardiology Department Of Medicine National Cardiovascular Center
-
Nakanishi Norifumi
Division Of Cardiology And Ccu National Cerebral And Cardiovascular Center
-
Nagaya Noritoshi
Department Of Regenerative Medicine And Tissue Engineering National Cardiovascular Center Research I
-
Motegi Katsuhiko
Division Of Cardiology Department Of Internal Medicine And Division Of Cardiac Sugery
-
Nagaya Noritoshi
Cardiovasclular Dynamics Dept National Cardiovascular Center
-
Shimizu Yoshito
Division Of Cardiology Department Of Medicine National Cardiovascular Center
-
Nagaya Noritoshi
Department Of Regenerative Medicine And Tissue Engineering National Cardiovascular Center Research I
-
Satoh Toru
Division Of Cardiology Department Of Medicine Kyorin University School Of Medicine
-
Kyotani Shingo
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center
関連論文
- Effects of Long-Term Intravenous Administration of Adrenomedullin (AM) Plus hANP Therapy in Acute Decompensated Heart Failure : A Pilot Study
- PE-234 Evaluation of the Effect of Valsartan on Target Lesion Revascularization after Percutaneous Coronary Intervention(PE040,Coronary Revascularization, PCI (Restenosis/Others) 2 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The J
- Usefulness of three-dimensional echocardiography in assessing right ventricular function in patients with primary pulmonary hypertension
- PE-234 Evaluation of the Effect of Valsartan on Target Lesion Revascularization after Percutaneous Coronary Intervention(PE040,Coronary Revascularization, PCI (Restenosis/Others) 2 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The J
- Sympathetic Stimulation Produces a Greater Increase in Both Transmural and Spatial Dispersion of Repolarization in LQT1 Than LQT2 Forms of Congenital Long QT Syndrome
- PE-196 Differences in central sleep apnea in right and left heart disorders(Heart failure, clinical(08)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-231 Can We Reduce β-Blockers to Half Doses in Patients With Stable Heart Failure during Long-term Administration of β-Blockers?(Heart Failure, Clinical 3 (M) : PJ39)(Poster Session (Japanese))
- Beta-Blocker Therapy in Patients with Dilated Cardiomyopathy : Different Effects on Heart Rate and the Role of the Selectivity of Beta-Blockers
- Different Time Course of Changes in Tricuspid Regurgitant Pressure Gradient and Pulmonary Artery Flow Acceleration After Pulmonary Thromboendarterectomy : Implications for Discordant Recovery of Pulmonary Artery Pressure and Compliance
- PJ-134 Does ARB Valsartan Reduce Cardiac Events after Coronary Stenting? : Results of the Coronary Atherosclerosis Reduction Project (CARP) at 1-Year follow-up(Restenosis basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Soc
- Heart Failure Elevates Serum Levels of Cibenzoline in Arrhythmic Patients(CLINICAL INVESTIGATION)
- Discordant Recovery of Pulmonary Artery Pressure and Compliance after Pulmonary Thromboendarterectomy in Patients with Chronin Thromboembolic Pulmonary Hypertension(Pulmonary Circulation 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulatio
- The Efficacy of Long-term Use of Bosentan for Idiopathic Pulmonary Arterial Hypertension (Pulmonary Circulation 4 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-432 Right Ventricular Function in Patients With Chronic Thromboembolic Pulmonary Hypertension, Before and After Thromboendarterectomy(Pulmonary Circulation 1 (H) : OJ53)(Oral Presentation (Japanese))
- Is There Any Exercise Parameter Useful for Predicting Future Cardiac Sudden Death?(Exercise Test/Cardiac Rehabilitation 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Combined Use of Peak VO2 and Exercise-induced ST Elevation Greatly Enhances the Predictability of Cardiac Deaths in Non-ischemic DCM Patients(Exercise Test/Cardiac Rehabilitation 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Soci
- Reduced Spontaneous Breath-by-breath VO2 Variations are Coupled with Elevated VE/VCO2 Slope(Exercise Test/Cardiac Rehabilitation 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OE-228 Improvement of prognosis in patients with idiopathic pulmonary hypertension with sildenafil for the last 4 years(Pulmonary circulation(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-234 Evaluation of the Effect of Valsartan on Target Lesion Revascularization after Percutaneous Coronary Intervention(PE040,Coronary Revascularization, PCI (Restenosis/Others) 2 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The J
- PE-234 Evaluation of the Effect of Valsartan on Target Lesion Revascularization after Percutaneous Coronary Intervention(PE040,Coronary Revascularization, PCI (Restenosis/Others) 2 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The J
- Dyssynchrony Imaging, A New Method to Assess Left Ventricular Dyssynchrony Based on Myocardial Strain : Comparison With Traditional Tissue Velocity Method(Echo/Doppler 13 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Current Challenge in Thromboendarterectomy for Chronic Pulmonary Thromboembolism with Pulmonary Hypertension ; Prompt Use of PCPS and MUF(Pulmonary Circulation 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-393 Adrenomedullin Enhances Angiogenic Potency of Bone Marrow Transplantation in a Rat Model of Hindlimb Ischemia(Angiogenesis 4 (IHD) : PE67)(Poster Session (English))
- Pulmonary Vasodilator Response to Adrenomedullin in Patients with Pulmonary Hypertension
- Beraprost sodium, an orally active prostacyclin analogue, has chronic hemodynamic effects in patients with secondary precapillary pulmonary hypertension
- Hemodynamic, Renal and Hormonal Effects of Ghrelin Infusion in Patients With Chronic Heart Failure
- PJ-134 Does ARB Valsartan Reduce Cardiac Events after Coronary Stenting? : Results of the Coronary Atherosclerosis Reduction Project (CARP) at 1-Year follow-up(Restenosis basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Soc
- PJ-828 Plasma Brain Natriuertic Peptide Predicts Prognosis in Patients with Pulmonary Arterial Hypertension Receiving Epoprostenol(Pulmonary circulation-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-284 Efficacy of Radiofrequency Catheter Ablation for Supraventricular Tachycardia in Patients with Pulmonary Hypertension(Arrhythmia, diagnosis/pathophysiology/EPS-14, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 4 Effects of Endothelin Receptor Antagonist for Pulmonary Arterial Hypertension(The Role of the Endothelin System in Cardiovascular Diseases, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Hemodynamic and Hormonal Effects of Beraprost Sodium, an Orally Active Prostacyclin Analogue, in Patients With Secondary Precapillary Pulmonary Hypertension
- Thyroid Microsomal Antibody Test Predicts Hyperthyroidism during Prostacyclin Therapy in Patients with Primary Pulmonary Hypertention
- Serum Uric Acid Level Increases in Proportion to the Severity of Pulmonary Thromboembolism
- Increased plasma vascular cell adhesion molecule-1 in pulmonary arterial hypertension were improved after long-term prostacyclin therapy
- Long Term Effects of Continuous Intravenous Prostacyclin on Hemodynamics and Cardiac Functions of Pulmonary Hypertension due to Collagen Disease
- Prognoses of Primary Pulmonary Hypertension and Chronic Majorvessel Thromboembolic Pulmonary Hypertension Determined from Cumulative Survival Curves
- Long-term Continuous Intravenous Infusion of Prostacyclin for Severe Primary Pulmonary Hypertension
- A New Model-Based Method of Reconstructing Central Aortic Pressure from Peripheral Arterial Pressure
- FRS-073 Noninvasive Estimation of Pulmonary Vascular Resistance by Doppler Echocardiography in Patients with Pulmonary Hypertension(Leading Edge in Echocardiographic Technologies(1)(I),Featured Research Session,The 72nd Annual Scientific Meeting of the Ja
- PJ-825 Noninvasive Evaluation of Right Ventricular Dysfunction and Disease Severity in Patients with Chronic Pulmonary Arterial Hypertension Using Strain Rate Imaging(Pulmonary circulation-3, The 71st Annual Scientific Meeting of the Japanese Circulation
- Effects of Long-Acting Beraprost Sodium (TRK-100STP) in Japanese Patients With Pulmonary Arterial Hypertension
- PJ-027 What Does Electrocardiographic Strain Pattern Mean in Aortic Stenosis? : Assessment With Myocardial Tissue Strain Imaging(Echo/Doppler 3 (I) : PJ5)(Poster Session (Japanese))
- Late Reperfusion (6-24 Hours After Onset) Improves Left Ventricular Function in Patients With Acute Myocardial Infarction
- A Phase III, Multicenter, Collaborative, Open-Label Clinical Trial of Sildenafil in Japanese Patients With Pulmonary Arterial Hypertension
- PJ-032 Clinical Significance and Limitation of Myocardial Washout Rate of Tc-99m-sestamibi in Left Ventricular Remodeling in Patients With Chronic Heart Failure(Nuclear Cardiology 2 (I) : PJ6)(Poster Session (Japanese))
- Patients With Dilated Cardiomyopathy With Attenuated Elevation of Cardiac Sympathetic Activity are Poor Responder to Carvedilol Therapy
- Prognostic Significance of Cardiac Metaiodobenzylguanidine Uptake and Plasma BNP Concentrations before The Carvedilol Therapy in Patients with Chronic Heart Failure
- Left Ventricular Diastolic Flow Propagates Into the Ventricle Not Linearly But Curvilinearly : Temporal Analysis of Propagation Velocity by Trajectory Imaging
- FRS-172 Decreased Serum Ghrelin Level in Patients with Acute Myocardial Infarction : Its Association with the Infarct Size and Time-dependent Recovery(Coronary Heart Disease : Basic Science (IHD) : FRS20)(Featured Research Session (English))
- PJ-537 A Combination of Oral Sildenafil and Beraprost Ameliorates Pulmonary Hypertension in Rats(Pulmonary Circulation 2 (H) : PJ90)(Poster Session (Japanese))
- Intravascular Ultrasonographic Assessments of pulmonary arterial intima-media complex and their therapeutic significance in Patients with Chronic Thromboembolic Pulmonary Hypertension
- PJ-045 Adrenomedullin Enhances Therapeutic Potency of Bone Marrow Transplantation for Acute Myocardial Infarction in Rats(Acute Myocardial Infarction, Basic 2 (IHD) : PJ8)(Poster Session (Japanese))
- Adrenomedullin Infusion during Ischemia/ Reperfusion Attenuates Left Ventricular Remodeling and Myocardial Fibrosis in Rats
- A Possible Role of Adrenomedullin as a Cell-Survival Mediator in Rat Coronary Ligation Model : The Association of Phosphatidylinositol 3-Kinase/Akt Signal
- Cardioprotective effect of adrenomedullin against ischemia/reperfusion injury in rats
- Left Atrial Function Preserves Pulmonary Circulatory Pressure During Pacing-Tachycardia and Contributes to Exercise Capacity in Patients With Idiopathic Dilated Cardiomyopathy in Sinus Rhythm, Whose Exercise is Limited by Dyspnea
- 1 Pulmonary arterial hypertension due to BMPR2 and ALK1 mutation(Current Therapeutic Strategy for Pulmonary Hypertension,Roundtable Discussion 6 (RT-06) (H),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Management of Continuous Intravenous Prostacyclin Therapy for Pulmonary Arterial Hypertention(The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Management of Continuous Intravenous Prostacyclin Therapy for Pulmonary Hypertension
- Adrenomedullin Gene Transfer Induces Therapeutic Angiogenesis in a Rabbit Model of Chronic Hindlimb Ischemia
- O_2 Extraction During Exercise Determines Training Effect After Cardiac Rehabilitation in Myocardial Infarction
- Excessive Ventilation After Acute Myocardial Infarction and Its Improvement in 4 Months
- FRS-055 Transplantation of Mesenchymal Stem Cells Improves Atrioventricular Conduction in Rat Model of Complete Atrioventricular Block(Regeneration, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-033 Capability of Contrast-enhanced Sonography in the Assessment of Neovascularization after Mesenchymal Stem Cell Transplantation in Rat Model of Hindlimb Ischemia(Echo/Doppler(03)(I),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of t
- 2 Cariorenal Association in Prognosis of Chronic Cardiovascular Disease and Renal Disease : Significance of Neurohumoral Activation(Cardiorenal Syndrome and Hypertensive Heart Diseases, The 71st Annual Scientific Meeting of the Japanese Circulation Societ
- FRS-184 Investigation of Gene Regulatory Mechanisms Governing Myocardial Energy Metabolism and the Effects of β-Blocker Therapy in Patients with Heart Failure(Heart Failure : Basic and Clinical Viewpoint (M) : FRS22)(Featured Research Session (English))
- Changes in myocardial gene expression associated with betablocker therapy in patients with chronic heart failure
- Altered gene expression of calcium regulatory protein in patients with chronic heart failure
- A Novel Long-Lasting Prostacyclin Agonist with Thromboxane Inhibitory Activity Attenuates Monocrotaline-Induced Pulmonary Hypertension in Rats(Pulmonary Circulation 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-394 Intravenous Administration of Mesenchymal Stem Cells Improves Cardiac Function in Rats With Acute Myocardial Infarction Through Angiogenesis and Myogenesis(Angiogenesis 4 (IHD) : PE67)(Poster Session (English))
- Repeated inhalation of adrenomedullin inhibits monocrotaline-induced pulmonary hypertension in rats
- Elevated circulating level of ghrelin in cachexia associated with chronic heart failure
- Cardiovascular and hormonal effects of subcutaneous administration of ghrelin, a novel growth hormone-releasing peptide, in healthy humans
- PE-118 Discrepancy between Electrocardiographic Type of Intraventricular Conduction Disturbances and Area of Mechanical Dyssynchrony : Assessment with Tissue Synchronization Imaging(Echo/Doppler 4 (I) : PE20)(Poster Session (English))
- Shunt Between the Ventricular Chamber and Coronary Arteries Preserves Left Ventricular Function in Acute Myocardial Infarction
- Increased Serum Levels of Myeloid-related Protein Is a Sensitive Marker for Acute Coronary Syndrome in Patients With Coronary Artery Disease
- Induction of Heme Oxygenase-1 Inhibits Monocyte Chemoattractant Protein-1 mRNA Expression in U937 Cells
- Insulin Resistance, Insulin Secretion, and Cardiovascular Mortality : Data from Hawaii-Los Angeles-Hiroshima Study
- Myocardial damage in the presence of severe mitral regurgitation can be assessed by systolic myocardial velocity gradient
- Glucose Tolerance and Cardiovascular Mortality : Comparison of 1997 American Diabetes Association and World Health Organization Criteria
- Oxygen Consumption Is Higher during Walking on Treadmill Than Walking on the Floor at the Same Speed in Cardiac Patients
- Comparison of Automatic Boundary Detection and Manual Tracing Technique in Echocardiographic Determination of Left Atrial Volume
- OE-249 Comparison of Hemodynamic Effects of Epoprostenol with Those of Sildenafil in Patients with Pulmonary Hypertension(Pulmonary circulation-1 (H) OE42,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulati
- FRS-029 Intravenous Administration of Adrenomedullin (AM) is Effective in Acute Heart Failure as a Therapeutic Drug(Clinical Heart Failure-Pathophysiology and Treatment, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-783 Plasma Adrenomedullin Levels as a Prognostic Marker in Patients with Chronic Stable Cardiovascular Disease : a Long-term Followup Study(Neurohumoral factors-3 (H) PJ137,Poster Session (Japanese),Poster Session (Japanese),The 70th Anniversary Annual
- 2 Utility of Sildenafil in Pulmonary Hypertension(Diagnosis and Treatment of Pulmonary Hypertension, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 3 Long-term Follow-up of Five Patients with Pulmonary Hypertension Who Take Bosentan(Which drug is useful for the treatment of pulmonary hypertension?,Topic 4 (TP4) (M),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Testosterone Associated with Low Body Mass Index Contribute to Male Predominance in Brugada Syndrome(Arrhythmia, Diagnosis/Pathophysiology/EPS 9 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-417 Level of Kidney Function as a Predictor for Mortality in Patients with Stable Chronic Cardiovascular Disease : Long-term Follow-up Study(Kidney/Renal circulation-2 (H) PE70,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of
- Lesion Severity and Hypercholesterolemia Determine Long-Term Prognosis of Vasospastic Angina Treated With Calcium Channel Antagonists
- PJ-116 The Association of Seropositivity to Chlamydia pneumoniae, Helicobacter pylori, and Cytomegalovirus with the Development of Hypertension in Japanese-Americans(Hypertension, Clinical 2 (H) : PJ20)(Poster Session (Japanese))
- OE-158 Enhanced Cardiac Production of Matrix Metalloproteinases-2 and-9 in Patients with Acute Myocardial Infarction : Its Attenuation by Statins(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 6 (IHD) : OE19)(Oral Presentation (English))
- PJ-410 Glomerular Filtration Rate (GFR) Contributes to Plasma BNP Level in Heart Failure Patients Even with Preserved Renal Function(Heart failure, clinical-12 (M) PJ69,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japane
- Determinants of Cardiac Output Increase Response to Exercise in Patients after Acute Myocardial Infarction : An Invasive Hemodynamic Analysis
- Left Ventricular Diastolic Dysfunction Unmasked by Exercise in Patients with Diabetes Mellitus after Acute Myocardial Infarction
- Changes in V02 Oscillations after 3-Month Concurrent Therapy with β-Blocker and Exercise Training in Patients with Heart Failure
- Combined Analysis of VE/VCO2 Slope and Slow Periodic VO2 Oscillations Accurately Predicts Future Cardiac Events in Dilated Cardiomyopathy
- 1 Hybrid Cell-gene Therapy for Pulmonary Hypertension Based on Phagocytosing Action of Endothelial Progenitor Cells(Plenary Session 8 (PL8) (IHD) : Toward Optimal Transplant Programs in Japan : from Cellular, Tissue and Solid Organ Aspects)(Special Progra
- Hybrid Cell-Gene Therapy for Pulmonary Hypertension Based on Phagocytosing Action of Endothelial Progenitor Cells
- A phase III, multicenter, collaborative, open-label clinical trial of sildenafil in Japanese patients with pulmonary arterial hypertension