Asymmetric Bioreduction of Cyclohexylphenyl Ketone to Its Corresponding Alcohol (+) Cyclohexylphenyl Alcohol by the Yeast Candida Magnoliae MY 1785

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概要

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• The screening of 129 fungal and yeasts strains yielded Candida magnoliae MY 1785 as a suitable biocatalyst fot the asymmetric bioreduction of cyclohexyphenyl ketone to its corresponding alcohol. Preparative amounts of pure alcohol weer prepared and purified. Polarimetry and chiral HPLC analyses indicated that C. magnotiae produced the (+) cyclohexylphenyl alcohol with an enantiomeric excess of 75%. A 55% bioconversion yield was achieved at the preparative scale.

• 公益社団法人日本生物工学会の論文
• 1997-04-25

著者

• Mathre David

  Department Of Bioprocess R&d And Department Of Process Research Merck Research Labortories

• Chartrain Michel

  Department Of Bioprocess R&d And Department Of Process Research Merck Research Labortories

• Greasham Randolph

  Department Of Bioprocess R&d And Department Of Process Research Merck Research Labortories

• Reamer Robert

  Department Of Bioprocess R&d And Department Of Process Research Merck Research Labortories

• PATEL SHASHIKANT

  Department of Bioprocess R&D and Department of Process Research, Merck Research Labortories

• SHINKAI ICHIRO

  Department of Bioprocess R&D and Department of Process Research, Merck Research Labortories

• Patel Shashikant

  Department Of Bioprocess R&d And Department Of Process Research Merck Research Labortories

• SHINKAI ICHIRO

  Department of Bioprocess R&D and Department of Process Research, Merck Research Labortories

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• Asymmetric Bioreduction of Cyclohexylphenyl Ketone to Its Corresponding Alcohol (+) Cyclohexylphenyl Alcohol by the Yeast Candida Magnoliae MY 1785

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