Inhibitory Activity of Berberine on DNA Strand Cleavage Induced by Hydrogen Peroxide and Cytochrome c

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概要

• 論文の詳細を見る

• The inhibitory activity of berberine on the DNA single-strand cleavage induced by hydrogen peroxide and cytochrome c was measured. Berberine effectively inhibited single-strand cleavage of DNA and its effectiveness was concentration-dependent. As the berberine concentration increased, the inhibitory activity against the DNA single-strand cleavage increased. The treatments with 1,5,10,50,and 100μm berberine showed 7.7,10.8,32.2,39.5,and 51.6% inhibition of DNA cleavage. This inhibitory activity of berberine against the DNA single-strand cleavage has never been reported previously. The inhibitory activity of berberine against DNA cleavage was stronger than caffeic acid and ascorbic acid. Berberine did not show strong hydroxyl radical scavenging activity, but showed strong superoxide anion radical quenching ability.

• 社団法人日本農芸化学会の論文
• 2001-02-23

著者

• Kim Sung-jin

  Semiconductor R&d Center Samsung Electronics Co. Ltd.

• Kim Sang-jin

  Division Of Bioscience And Biotechnology Woosuk University

• CHOI Dong-Seong

  Division of Bioscience and Biotechnology, Woosuk University

• JUNG Mun

  Division of Food Science and Technology, Woosuk University

• Jung Mun

  Division Of Food Science And Technology Woosuk University

• Choi Dong-seong

  Division Of Bioscience And Biotechnology Woosuk University

関連論文

• The Study on the Reaction Mechanism of HDP-SiOF Film and Inter-Metal-Dielectric Application
• The Study on the Reaction Mechanism of HDP-SiOF Film and Inter-Metal-Dielectric Application
• Inhibitory Activity of Berberine on DNA Strand Cleavage Induced by Hydrogen Peroxide and Cytochrome c

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