Preparation of 4-(4'-Hydroxyanilino)-5-anilinophthalimide and 4,5-Bis-(4'-hydroxyanilino)-phthalimide by microbial Hydroxylation
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概要
- 論文の詳細を見る
A microbial screening indicated that two fungal strains, Beauveria bassiana DSM 1344=ATCC 7159 and Cunninghamella elegans DSM 1908=ATCC 9245,as well as four bacterial strains belonging to the genus Streptomyces were able to hydroxylate 4,5-dianilinophthalimide (DAPH, CGP52411) to 4-(4'-hydroxyanilino)-5-anilinophthalimide. Cunninghamella elegans DSM 1908 turned out to be the most active biocatalyst and was also able to form the dihydroxy derivative, 4,5-bis(4'-hydroxyanilino)phthalimide. The reaction for the monohydroxylatd biotransformation product was carried out on a preparative scale, and the culture conditions for the formation of 4-(4'-hydroxyanilino)-5-anilinophthalimide with this strain were optimized.
- 社団法人日本農芸化学会の論文
- 1999-08-23
著者
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Weidner Stefan
Institute Of Enzyme Technology Heinrich-heine-university Dusseldorf Research Center Julich
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GOEKE Klaus
Novartis Pharma AG, Research, Core Technology Area
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TRINKS Uwe
Novartis Pharma AG, Research, Core Technology Area
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TRAXLER Peter
Oncology Research, Novartis Pharma Inc.
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UCCI-STOLL Katharina
Novartis Pharma AG, Research, Core Technology Area
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GHISALBA Oreste
Novartis Pharma AG, Research, Core Technology Area
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Traxler P
Oncology Research Novartis Pharma Inc.
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Trinks Uwe
Novartis Pharma Ag Research Core Technology Area
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Goeke Klaus
Novartis Pharma Ag Research Core Technology Area
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Ghisalba Oreste
Novartis Pharma Ag
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Ghisalba Oreste
Novartis Pharma Ag Research Core Technology Area
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Ucci-stoll Katharina
Novartis Pharma Ag Research Core Technology Area
関連論文
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