Chemo-enzymatic Synthesis of both Enantiomers of myo-Inositol 1,3,4,5-tetrakisphosphate

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概要

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• D-Ins (1,3,4,5)P_4 and unnatural L-Ins (1,3,4,5)P_4 were prepared in gram-quantities from D-and L-2,6-di-O-benzyl-myo-inositol by a chemical phosphorylation and deprotection step in high yield and purity without extensive purification. The optically pure benzyl derivatives were obtained by enzyme-catalyzed resolution of racemic 2,6-di-O-benzyl-myo-inositol under acyl-transfer conditions in vinyl acetate as the acyl donor. The lipase of Candida antarctica only acetylated regio-and enantio-selectively the L-enan-tiomer, providing exclusively L-5-acetyl-2,6-di-O-benzyl-myo-inositol, whereas the D-enantiomer remained unchanged.

• 社団法人日本農芸化学会の論文
• 1999-08-23

著者

• Ghisalba Oreste

  Novartis Pharma Ag Core Technology Area

• Ghisalba Oreste

  Novartis Pharma Ag

• LAUMEN Kurt

  Novartis Pharma AG, Core Technology Area

• Laumen Kurt

  Novartis Pharma Ag Core Technology Area

関連論文

• Preparation of 4-(4'-Hydroxyanilino)-5-anilinophthalimide and 4,5-Bis-(4'-hydroxyanilino)-phthalimide by microbial Hydroxylation
• Preparative 2'-Reduction of ATP Catalyzed by Ribonucleotide Reductase Purified by Liquid-Liquid Extraction
• Chemo-enzymatic Synthesis of both Enantiomers of myo-Inositol 1,3,4,5-tetrakisphosphate
• Enzyme-assisted Preparation of D-tert.-Leucine(Organic Chemistry)

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