Inhibition of Immunoglobulin Production Stimulating Activity of Glyceraldehyde-3-phosphate Dehydrogenase by Nucleotides

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概要

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• We have previously identified glyceraldehyde-3-phosphate dehydrogenase as an immunoglobulin production stimulating factor (IPSF) which facilitated immunoglobulin production by hybridomas and lymphocytes. The IPSF activity of this enzyme was suppressed by the coexistence of some sorts of nucleotides. We now report that the IPSF effect of GAPDH was suppressed by the coexistence of DNA, the inhibiting effect of degraded DNA being inferior to that of long-chain DNA. Both single-stranded and double-stranded synthetic polyribonucleotides also inhibited the IPSF activity of GAPDH. Moreover, nicotinamide adenine dinucleotide (NAD^+) repressed the IPSF effect.

• 社団法人日本農芸化学会の論文
• 1998-06-23

著者

• Sugahara Takuya

  College Of Agriculture Ehime University

• SASAKI Takeshi

  College of Agriculture, Ehime University

• Sasaki Takeshi

  College Of Agriculture Ehime University

関連論文

• Inhibition of Immunoglobulin Production Stimulating Activity of Glyceraldehyde-3-phosphate Dehydrogenase by Nucleotides
• Enhancement of IgM Production by Human Peripheral Blood Lymphocytes by Rice Fermented Seasoning under Serum-Free Cultivation

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