Enzymatic Optical Resolution of Dibenzoxepins and Its Application to an Optically Active Antiallergic Agent with Thromboxane A_2 Receptor Antagonistic Activity

スポンサーリンク

概要

• 論文の詳細を見る

• Methyl (±)-11-(2-hydroxyethyl)thio-6, 11-dihydrodibenz[b, e]oxepin-2-carboxylate (5) was enantioselectively acylated with acetic anhydride in an organic medium by Lipase Amano P to give methyl (-)-11-(2-acetoxyethyl)thio-6, 11-dihydrodibenz[b, e]oxepin-2-carboxylate (8), and the (+)-enantiomer by Lipase Sigma Type VII. Using Lipase Amano P, (+)- and (-)-(5) could be prepared with high optical purity (84-94% e.e.). These products were respectively converted to (+)- and (-)-KW-4099, which had antiallergic activity with complete retention of the optical purity.

• 社団法人日本農芸化学会の論文
• 1993-07-23

著者

• Tomioka Shinji

  Sakai Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Kuge Yukihiro

  Sakai Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Shioga Kenji

  Sakai Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Sugaya Toru

  Sakai Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• Sugaya Toru

  Sakai Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

関連論文

• Production of Dihydrofolate Reductase by Cloned Escherichia coli and Its Application to Asymmetric Synthesis of l-Leucovorin
• NADPH Regeneration by Glucose Dehydrogenase from Gluconobacter scleroides for l-Leucovorin Synthesis : Asymmetric Synthesis of l-Leucovorin. Part 2. See ref. 1.
• Microbial Hydroxylation of 2-Phenylpropionic Acid(Biological Chemistry)
• Enzymatic Optical Resolution of Dibenzoxepins and Its Application to an Optically Active Antiallergic Agent with Thromboxane A_2 Receptor Antagonistic Activity

スポンサーリンク