Significance of Monocyte Chemotactic Protein-1 and Thymidine Phosphorylase in Angiogenesis of Human Cardiac Myxoma
スポンサーリンク
概要
- 論文の詳細を見る
Angiogenesis is indispensable to tumor development and proliferation. The aim of this study was to investigate whether the expression of monocyte chemotactic protein-1 (MCP-1) and of thymidine phosphorylase (TP) correlates with the angiogenesis and clinicopathologic features in cardiac myxoma. Paraffin-embedded specimens of 17 resected cardiac myxomas were immunohistochemically stained for MCP-1, CC chemokine receptor-2 (CCR-2), TP, CD31, and CD68. Correlations among MCP-1 expression, TP expression, microvessel count (determined by CD31 staining), macrophage count (determined by CD68 staining), and the clinicopathologic features of the patients were analyzed statistically. Immunohistochemical analysis revealed that MCP-1 and IP were expressed in myxoma cells, as well as in stromal cells such as infiltrating cells, fibroblast-like cells and endothelial cells. CCR-2 was abundantly expressed in stromal infiltrating cells in all myxomas and occasionally in the endothelial cells. In the tumor stroma, the major source of MCP-1, TP and CCR-2 was macrophages, and the sites of positive staining for MCP-1, TP and CCR-2 matched in most of the myxomas. Statistical analysis revealed that the proportions of MCP- 1-positive myxoma and stromal cells, and TP-positive myxoma and stromal cells significantly correlated with increased microvessel count. The proportions of MCP-1-positive myxoma and stromal cells significantly correlated with the proportion of TP-positive stromal cells. The mean microvessel count in myxomas with both high tumor and high stromal MCP-1 or IP expression was significantly higher than that in myxomas with low tumor and low stromal MCP-1 or TP expression. Small tumors (≥55mm in diameter) exhibited high MCP-1 or TP expression, and the microvessel count in small tumors was significantly higher than in large myxomas. Although the difference was not significant, myxomas with both high tumor and high stromal MCP-1 expression had a higher macrophage count than other myxomas. These results indicate that in cardiac myxoma, MCP-1 and TP may be regarded as important angiogenic signals accompanying growth.
- 社団法人日本循環器学会の論文
- 2002-12-20
著者
-
Takayama Kei
Second Department Of Surgery Shinshu University School Of Medicine
-
Amano J
信州大学 医学部外科
-
KITAHARA Hiroto
Department of Cardiovascular Surgery, Shinshu University School of Medicine
-
KONO Tetsuya
Department of Cardiovascular Surgery, Shinshu University School of Medicine
-
Amano Jun
Second Department of Surgery, Shinshu University School of Medicine
-
KOIDE NAOHIKO
Department of Surgery, Shinshu University School of Medicine
-
KOIDE NAOHIKO
Second Department of Surgery, Shinshu University School of Medicine
-
ZHANG Tianshu
Department of Surgery, Shinshu University School of Medicine
-
Zhang Tianshu
Second Department of Surgery, Shinshu University School of Medicine
-
Wada Yuko
Second Department of Surgery, Shinshu University School of Medicine
-
Tsukioka Katsuaki
Second Department of Surgery, Shinshu University School of Medicine
-
Kono Tetsuya
Second Department of Surgery, Shinshu University School of Medicine
-
Kitahara Hiroto
Second Department of Surgery, Shinshu University School of Medicine
-
Amano Jun
Second Department Of Surgery Shinshu University School Of Medicine
-
Wada Yuko
Department Of Surgery Shinshu University School Of Medicine
-
Kono Tetsuya
Department Of Surgery Shinshu University School Of Medicine
-
Koide Naohiko
Department Of Surgery Shinshu University School Of Medicine
-
Koide Naohiko
Second Department Of Surgery Shinshu University School Of Medicine
-
Zhang Tianshu
Department Of Surgery Shinshu University School Of Medicine
-
Tsukioka Katsuaki
Second Department Of Surgery Shinshu University School Of Medicine
-
Amano J
Dep. Of Surgery Shinshu Univ. School Of Medicine
-
Kitahara Hiroto
Second Department Of Surgery Shinshu University School Of Medicine
-
Wada Yuko
Department Of Cardiovascular Surgery Shishu University Of Medicine
関連論文
- The Application of Magnetic Cell Sorter (MACS) to Detect Fetal Cells in Maternal Peripheral Blood
- GERMLINE MUTATIONS OF THE APC GENE IN TWO JAPANESE ADENOMATOUS POLYPOSIS PATIENTS
- Mitral Stenosis and Regurgitation With Systemic Lupus Erythematosus and Antiphospholipid Antibody Syndrome
- Heart failure in the dog induced by rapid ventricular pacing using a newly designed cardiac pacemaker, MCMS-0102
- Coronary Arteriovenous Fistula With Annuloaortic Ectasia and Aortic Regurgitation
- Auto Iris Pigment Epithelial Cell Transplantation in Patients with Age-Related Macular Degeneration : Short-Term Results
- Molecular Genetic Analysis of ABCR Gene in Japanese Dry Form Age-Related Macular Degeneration
- Ectopic Transcription and the Possibility of RNA Editing of the Human Arrestin Gene
- Successful Surgical Treatment for Acute Aortic Dissection in Pregnancy with Marfan's Syndrome
- Update of Surgical Treatment for PAD(An Update on the Contemporary Management of Peripheral Arterial Disease, The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Pulmonary Embolism due to Right Ventricular Thrombus in a Case of Behcet's Disease
- Two Cases of Early Carcinoma of a Reconstructed Gastric Tube after Esophagectomy Treated Extendedly with Endoscopic Submucosal Dissection
- Postoperative Suppression of Inflammatory Cytokines After Distal Gastrectomy in Elderly Patients
- Basaloid-Squamous Carcinoma of the Esophagus Treated by Preoperative Chemotherapy : Report of Two Cases
- A squamous cell carcinoma of the gastric cardia showing submucosal progression
- Co-Occurrence of Mucoepidermoid Carcinoma and Squamous Cell Carcinoma of the Esophagus: Report of a Case
- Four resections for hepatic metastasis from gastric cancer: histochemical analysis of cell proliferation, apoptosis, and angiogenesis
- Reresection for Local Recurrence of Rectal Cancer
- Castleman's disease arising from the chest wall
- Giant intraatrial septal aneurysm originating from a branch of the left coronary artery
- Case of Orbital Sebaceous Carcinoma Developing Twenty-Seven Years After Enucleation
- Genetically engineered Bifidobacterium longum for tumor-targeting enzyme-prodrug therapy of autochthonous mammary tumors in rats
- Cardiac Myxoma : Its Origin and Tumor Characteristics
- Small Cell Carcinoma of the Esophagus with Reference to Alternating Multiagent Chemotherapy : Report of Two Cases
- Significance of Monocyte Chemotactic Protein-1 and Thymidine Phosphorylase in Angiogenesis of Human Cardiac Myxoma
- Cloned Cytosine Deaminase Gene Expression of Bifidobacterium longum and Application to Enzyme/Pro-drug Therapy of Hypoxic Solid Tumors(Biochemistry & Molecular Biology)
- Stromal sarcoma of the breast with leiomyosarcomatous pattern
- The Likely Transformation of Papillary Thyroid Carcinoma into Anaplastic Carcinoma During Postoperative Radioactive Iodine-131 Therapy : Report of a Case
- Solitary Brain Metastasis from Papillary Thyroid Carcinoma in a Patient with Depression : Report of a Case
- Multiple Branchial Cleft-Like Cysts in a Female Patient with Hashimoto's Thyroiditis
- Urinary Bladder Injury During Inguinal Herniorrhaphy in a Renal Transplant Patient : Report of a Case
- Tumor Marker Levels Elevate False-Positively in Postsurgical Breast Cancer Patients with High sGPT Levels or with Receiving Oral 5-FU or Its Derivatives
- Primary Cardiac Malignant Fibrous Histiocytoma in the Right Ventricular Infundibulum Treated With a Cavo-Pulmonary Shunt and Coronary Embolization
- SUCCESSFUL MANAGEMENT OF METASTASIS-INDUCED PANCREATITIS BY ENDOSCOPIC PANCREATIC DUCT STENTING IN A CASE OF LARGE CELL LUNG CANCER
- Multiple Carcinoids of the Duodenum Accompanied by Type I Familial Multiple Endocrine Neoplasia
- Briateral Synchronous Spindle Cell, Apocrine and Scirrhous Carcinoma Breast Cancer in a Case of Malignant Lymphoma
- Squamous Cell Carcinoma Arising from Thyroglossal Duct Remnants:Report of a Case and Results of Immunohistochemical Studies
- A Case of Occult Breast Cancer with Paraneoplastic Polyneuropathy
- Postoperative Outcome of Insufficient Surgery for Small Differentiated Thyroid Carcinoma
- Expression of Fibroblast Growth Factor-2 and Fibroblast Growth Factor Receptor-1 in Thyroid Diseases : Difference between Neoplasms and Hyperplastic Lesions
- Development of Graves' Disease after Surgical Treatment for Thyroid Nodules : Report of Four Cases
- Development of Graves' Disease from Asymptomatic Autoimmune Thyroiditis: A Case Report
- A Case of Influenza Subtype A Virus-Induced Fulminant Myocarditis : An Experience of Percutaneous Cardio-Pulmonary Support (PCPS) Treatment and Immunohistochemical Analysis
- Anesthetic management of simultaneous coronary artery bypass grafting and cardiac pheochromocytoma resection under cardiopulmonary bypass
- An Instrument Capable of Grading Visual Function : Results from Patients with Retinitis Pigmentosa
- Novel MEN1 gene mutations in familial multiple endocrine neoplasia type 1
- Graft Arterial Disease (GAD) : A Model for Investigating Inflammation and T Cell-Mediated Immunity in Coronary Arteriosclerosis
- Successful Resection of Intracardiac Invasive Thymoma with Right Ventricular Inflow Tract Occlusion
- Functional Analysis after Auto Iris Pigment Epithelial Cell Transplantation in Patients with Age-Related Macular Degeneration
- Clinicopathologic features and histochemical analyses of proliferative activity and angiogenesis in small cell carcinoma of the esophagus
- Gastric Small Cell Carcinoma Successfully Treated by Surgery and Postoperative Chemotherapy Consisting of Cisplatin and S-1 : Report of a Case
- Immunohistochemical Studies of Vascular Volume and Proliferative Activity in Squamous Cell Carcinoma of the Esophagus
- Small-intestinal sarcomatoid carcinoma with superior vena cava syndrome
- Immunohistochemical Expression of bcl-2 Protein in Squamous Cell Carcinoma and Basaloid Carcinoma of the Esophagus
- Successful treatment of supraventricular tachyarrhythmias with landiolol during hemodialysis in a patient after receiving cardiac surgery
- Killian-Jamieson Diverticulitis with Cervical Cellulitis : Report of a Case
- Giant cavernous hemangioma of the liver : is tumor size a risk factor for hepatectomy?
- Targeting solid tumors with non-pathogenic obligate anaerobic bacteria
- Strong Enhancement of Recombinant Cytosine Deaminase Activity in Bifidobacterium longum for Tumor-Targeting Enzyme/Prodrug Therapy
- Granulocyte colony stimulating factor-producing collision tumor of the gastric cardia
- Bilateral Iliopsoas Hematomas Complicating Anticoagulant Therapy
- Infectious Endocarditis Associated with Subarachnoid Hemorrhage, Subdural Hematoma and Multiple Brain Abscesses
- Full-thickness chest-wall resection followed by thorax reconstruction for recurrent malignant phyllodes tumor
- Quadricuspid Aortic Valve with Ascending Aortic Aneurysm : A Case Report and Histopathological Investigation
- Mediastinoscopy-assisted esophagectomy for esophageal cancer in patients with serious comorbidities
- Two cases of acute renal hemorrhage undergoing maintenance hemodialysis after concurrent administration of cinacalcet
- Prosthetic valve endocarditis caused by Staphylococcus capitis: report of 4 cases
- Indicators of Survival after Open Repair of Ruptured Abdominal Aortic Aneurysms and an Index for Predicting Aneurysmal Rupture Potential
- Paravalvular Abscess of the Mitral Valve with Fistula to the Left Ventricle and Detachment of the Coronary Sinus in a Young Woman
- Treatment of Prosthetic Graft Infection after Thoracic Aorta Replacement
- Cardiac Papillary Fibroelastoma: Report of Three Cases
- Pericoronary Pseudotumor Caused by Helicobacter Cinaedi:A Case Report