狭心症に対するpropranolol とAlprenololとの効果 : 二重盲検法による検討

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The effects of propranolol and alprenolol on angina pectoris were investigated in a double-blind cross-over trial. Materials and Methods The protocol for the present trial including the criteria for admission of the patients was decided after discussion by all of the doctors involved. Twenty-one out-patients with typical angina pectoris due to coronary atherosclerosis in whom frequency of anginal attacks had been stable for a long period of time were selected for the trial. As a rule, sublingual use of nitrate preparations to prevent attacks was suspended, however, other drugs such as coronary vasodilators, sedatives, etc. which had been previously administered were continued in the same dosages throughout this investigation period. The trial period consisted of two weeks each for the three periods (the I, II and III periods) in which the following three combinations of the test drugs were allocated to the patients in random order: propranolol tablets (10mg × 6 tabs/ day) with placebo for alprenolol capsules (6 caps/ day); alprenolol capsules (25mg ×6 caps/day) with placebo for propranolol tablets (6 tabs/day); and placebo tablets (6 tabs/day) with capsules (6 caps/day). Dosages of propranolol and alprenolol were decided according to equipotent dose ratio reported by ÅBLAD. One to two weeks prior to and after the trial period were regarded as the pre-trial and follow-up periods. The daily number of anginal attacks and daily consumpation of nitroglycerin tablets and test drugs were recorded by each patient in a diary (Fig. 1-a). At the end of each period, the doctors recorded the severity, duration and precipitating factors of the attacks along with the side-effects (Fig. 1-b). Heart rate, blood pressure and ECG before and after Master's double two-step test were also recorded. The frequency of anginal attacks is much liable to be affected by alterations in various factors such as daily working and emotional state of patients, weather, etc. When investigating the anti-anginal effects of a drug, therefore, an assessment of the frequency of the attacks alone is considered to be insufficient. In this trial, investigations were made on the following items: 1. Frequency of the attacks and consumption of nitroglycerin tablets were expressed in terms of number per week. The differences between the periods were analyzed by the two-tailed Wilcoxon matched-pairs signed-ranks test.
社団法人日本循環器学会の論文
1970-07-20

狭心症に対するpropranolol とAlprenololとの効果 : 二重盲検法による検討

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