COMPUTERIZED M-MODE ECHOCARDIOGRAPHIC ASSESSMENT OF LEFT VENTRICULAR DIASTOLIC FUNCTION IN PATIENTS WITH FAMILIAL AMYLOID POLYNEUROPATHY : 51st Annual Meeting of the Japanese Circulation Society
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概要
- 論文の詳細を見る
To determine left ventricular diastolic properties in patients with familial amyloid polyneuropathy, 23 patients were studied by digitized M-mode echocardiography and were compared with 15 age-matched normal subjects. None of the patients had restrictive ventricular physiology and all but two showed normal left ventricular fractional shortening. Both the normalized peak rate of diastolic increase in left ventricular internal dimension and the normalized peak rate of diastolic thinning of posterior wall were significantly lower in patients than in normal subjects (2.0 ± 0.8 vs 3.0 ± 0.4 sec^<-1> ; p<0.001, and 2.5 ± 1.2 vs 5.8 ± 1.0 sec^<-1> ; p<0.001, respectively). The left ventricular isovolumic relaxation time in patients was 91.5 ± 22.2 msec, compared with 64.0 ± 2.6 msec in normal subjects (p<0.001). Of the 18 patients without clinical evidence of overt heart disease, 12 had normal ventricular wall thickness and normal fractional shortening, but 10 of the 12 exhibited some abnormalities in diastolic properties. In addition,indexes of diastolic function were significantly related to ventricular wall thickness alone. These findings indicate that left ventricular diastolic abnormalities precede the development of clinically overt heart disease, ventricular wall thickening, and systolic dysfunction and may be related to intramyocardial amyloid infiltration with resultant fibrosis in patients with familial amyloid polyneuropathy.
- 社団法人日本循環器学会の論文
- 1990-01-20
著者
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Sekiguchi Morie
First Department Of Internal Medicine Shinshu University School Of Medicine
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Kinoshita Osamu
Department of Cardiovascular Medicine, Azumino Red Cross Hospital
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Sekiguchi Morie
Saiseikai Kumamoto Hospital
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Sekiguchi Morie
International Cardiomyopathy Study Section Japan Research Promotion Society For Cardiovascular Disea
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Hongo Minoru
The First Department Of Internal Medicine Shinshu University School Of Medicine
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SEKIGUCHI Morie
the First Department of Internal Medicine, Shinshu University School of Medicine
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Kinoshita Osamu
The First Department of Internal Medicine, Shinshu University, School of Medicine
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YAMADA Hiroyoshi
The 1st Department of Internal Medicine,Shinshu University
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YAMADA Hiroyoshi
the Faculty of Engineering, Niigata University
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MISAWA TAKUO
The First Department of Internal Medicine, Shinshu University School of Medicine
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KONO JUN
The First Department of Internal Medicine, Shinshu University School of Medicine
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OKUBO SHINICHI
The First Department of Internal Medicine, Shinshu University School of Medicine
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Hongo Minoru
School Of Medicine Shinshu University
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Sekiguchi Morie
The First Department Of Internal Medicine Shinshu University School Of Medicine
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Sekiguchi Morie
The 1st Department Of Internal Medicine Shinshu University
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Yamada Hiroyoshi
The First Department Of Internal Medicine Shinshu University School Of Medicine
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Kono Jun
The First Department Of Internal Medicine Shinshu University School Of Medicine
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Misawa Takuo
First Department Of Internal Medicine Shinshu University School Of Medicine
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Misawa Takuo
Department Of Internal Medicine Kofu National Hospital
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Okubo Shinichi
The First Department Of Internal Medicine Shinshu University School Of Medicine
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Sekiguchi Morie
The Heart Institute Of Japan Tokyo Women 's Medical College Tokyo
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Sekiguchi Morie
Dept. Of Cardiovascular Surqery The Heart Institute Of Japan Tokyo Women's Medical College
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Sekiguchi Morie
The Heart Institute Of Japan
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Kinoshita Osarnu
The First Department Of Internal Medicine Shinshu University School Of Medicine
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Yamada Hiroyoshi
The Faculty Of Engineering Niigata University
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Sekiguchi Morie
International Cardiomyopathy Study Section Japan Research Promotion Society For Cardiovascular Disea
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Sekiguchi Morie
Dept. Of Cardiology The Heart Institute Japan Tokyo Women's Medical College.
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Misawa Takuo
The First Department Of Internal Medicine Shinshu University School Of Medicine
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Hongoh Minoru
Department Of Cardiovascular Medicine
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