Low-Dose Rosuvastatin Improves Arterial Stiffness in High-Risk Japanese Patients With Dyslipdemia in a Primary Prevention Group : A Comparison With Fluvastatin
スポンサーリンク
概要
- 論文の詳細を見る
Background: The treatment effects of rosuvastatin on arterial stiffness were assessed and compared to those of fluvastatin in high-risk Japanese patients with dyslipidemia in a primary prevention group. Methods and Results: Patients were randomly assigned to either 2.5-5mg/day of rosuvastatin (Group A) or 20-40mg/day of fluvastatin (Group B) and followed up for 12 months. In Group A (n=38), there was a progressive reduction in brachial-ankle pulse wave velocity (baPWV) along with a decrease in the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (L/H) ratio and high-sensitivity C-reactive protein (hsCRP), and the change in baPWV correlated significantly with that of the L/H ratio and that of hsCRP after rosuvastatin treatment. In Group B (n=37), although fluvastatin achieved a significant improvement in baPWV, L/H ratio, and hsCRP, baPWV was significantly greater than that in Group A and showed a significant correlation with that of hsCRP alone after fluvastatin treatment. In a subgroup of patients (n=26), switching from fluvastatin to rosuvastatin further improved baPWV and the L/H ratio without altering hsCRP after 12 months. Conclusions: Low-dose rosuvastatin would be more effective than fluvastatin in improving arterial stiffness in high-risk Japanese patients with dyslipidemia. The results suggest that improvement in arterial stiffness by rosuvastatin mainly depends on its strong lipid-lowering effects, whereas that by fluvastatin is strongly dependent on the pleiotropic effects, especially an anti-inflammatory action. (Circ J 2011; 75: 2660-2667)
- 社団法人 日本循環器学会の論文
- 2011-10-25
著者
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Izawa Atsushi
Department Of Cardiovascular Medicine Shinshu University
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Izawa Atsushi
Division Of Cardiovascular Science Shinshu University Graduate School Of Medicine
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Izawa Atsushi
Department Of Cardiovascular Medicine Shinshu University Graduate School Of Medicine
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Yoshida Yukihiko
Division Of Cardiology Nagoya Dai-ni Red Cross Hospital Cardiovascular Center
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Hongo Minoru
Department of Cardiovascular Medicine, Shinshu University School of Health Sciences
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Kinoshita Osamu
Department of Cardiovascular Medicine, Azumino Red Cross Hospital
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Hongo Minoru
Department Of Cardiovascular Medicine Shinshu University School Of Health Sciences
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Hidaka Hiroya
Department Of Clinical Laboratory Medicine Shinshu University School Of Health Sciences
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Ikeda U
Department Of Cardiovascular Medicine Shinshu University School Of Medicine
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Ikeda Uichi
Department Of Cardiology Jichi Medical School
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Kinoshita Osamu
Department Of Cardiovascular Medicine And Regeneration Shinshu University Graduate School Of Medicin
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Kumazaki Setsuo
Department Of Cardiovascular Medicine Shinshu University Graduate School Of Medicine
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Tomita Takeshi
Department Of Cardiovascular Medicine Shinshu University Graduate School Of Medicine
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Yazaki Yoshikazu
Departments Of Cardiovascular Medicine Shinshu University School Of Medicine
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Yazaki Yoshikazu
The Division Of Cardiovascular Medicine Shinshu University School Of Medicine
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Kinoshita Osamu
The Division Of Cardiovascular Medicine Shinshu University School Of Medicine
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Ikeda Uichi
The Departments Of Cardiology Echi Medical School
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Ikeda Uichi
Departmrnt Of Cardiology Shinshu University
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Ikeda Uichi
The Department Of Cardiology Jichi Medical School
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Ikeda Uichi
Department Of Cardiology Shinshu University School Of Medicine
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Yazaki Yoshikazu
Division Of Cardiology National Matsumoto Medical Center Matsumoto Hospital
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Hongoh Minoru
Department Of Cardiovascular Medicine Shinshu University School Of Health Sciences
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Kinoshita Osamu
Department Of Cardiology Shinshu University School Of Medicine
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Ikeda Uichi
Division Of Cardiovascular Sciences Department Of Organ Regeneration Shinshu University Graduate School Of Medicine
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Hongoh Minoru
Department Of Cardiovascular Medicine
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TOMITA TAKESHI
Department of Animal Breeding, Faculty of Agriculture, Nagoya University
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Kinoshita Osamu
Department of Cardiac Surgery, Graduate School of Medicine, University of Tokyo
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