PLASMA LIPOPROTEIN(a) LEVELS AND FIBRINOLYTIC ACTIVITY IN PATIENTS WITH UNSTABLE ANGINA

概要

論文の詳細を見る
The relationships between plasma Lipoprotein(a) (Lp(a)) levels and plasminogen activator inhibitor (PAI) activity and tissue plasminogen activator (t-PA) antigen levels were studied in 15 patients with unstable angina. Plasma levels of Lp(a) (mg/dl) were significantly higher in patients with unstable angina after treatment 2 weeks than on admission (19.7±2.8 vs 14.6±2.3, p<0.01). On the other hand, the plasma levels of PAI activity (IU/ml) and t-PA antigen (ng/ml) in patients with unstable angina were significantly higher on admission than after treatment (PAI activity: 11.4±1.4 vs 7.7±1.5, t-PA antigen: 8.7±0.9 vs 7.0±0.9, p<0.01). We conclude that patients with unstable angina have re duced fibrinolytic capacity, as indicated by increased PAI activity, and that the plasma Lp(a) level may be decreased due to binding with fibrin during the acute stage of unstable angina.
社団法人日本循環器学会の論文
1993-09-20