Impaired Ventricular Relaxation During Myocardial Ischemia and After Repercussion in Isolated Perfused Canine Hearts : SYMPOSIUM ON MECHANICS OF CONTRACTION AND RELAXATION OF THE ISCHEMIC MYOCARDIUM : 50th Annual Scientific Session of Japanese Circulation
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概要
- 論文の詳細を見る
The goal of this study was to investigate the mechanisms of impaired relaxation in ischemic and reperfused hearts without asynergic wall motion. to test the hypothesis that muscle elongation during ischemia does not improve the slowed relaxation, the time constant (T) of the isovolumic left ventricular pressure decay was obtained during volume loading in 14 isolated perfused canine hearts. In the nonischemic condition (coronary perfusion pressure: 107±3 mmHg), T progressively decreased as the peak left ventricular pressure was increased by volume loading. In contrast, in the ischemic condition (coronary perfusion pressure: 51±3 mmHg), T did not decrease despite an increase in peak left ventricular pressure by volume loading. These results indicate that during ischemia the impaired relaxation is not improved by an increase in preload. Moreover, reperfusion after a brief ischemia also increased T despite an increase in the contractile force, i.e., left ventricular pressure. The maximal change in the relaxation rate occurred much earlier than the maximal change in the relaxation rate occurred much earlier than the maximal overshoot of the contractile force and coincided with an increase in coronary blood flow. These results indicate that prolongation of relaxation immediately after reperfusion is partly attributable to an increase in the electile force induced by the refilling of the coronary arteries. These mechanisms of impaired relaxation during ischemia and reperfusion may deteriorate ventricular filling and hence, cardiac output.
- 社団法人日本循環器学会の論文
- 1987-01-20
著者
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Ishida Y
Department Radiology And Nuclear Medicine National Cardiovascular Center
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Ishida Yoshio
First Department Of Medicine And Faculty Of Medical Information Science Osaka University School Of M
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Kitakaze Masafumi
The First Department Of Medicine Osaka University School Of Medicine
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Inoue Michitoshi
Osaka University School Of Medicine
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Inoue Michitoshi
The First Department Of Medicine Osaka University Medical School
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Inoue M
Osaka National Hospital
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Ishida Yoshio
The First Department Of Medicine Osaka University School Of Medicine
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Ishida Yoshio
First Department Of Medicine And Faculty Of Medical Information Science Osaka University School Of M
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HORIM MASATSUGU
The First Department of Medicine,Osaka University School of Medicine
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