VIROLOGICAL STUDY OF IDIOPATHIC CARDIOMYOPATHY : Serological study of virus antibodies and immunofluorescent study of myocardial biopsies
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概要
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In 113 patients with idiopathic cardiomyopathy paired sera obtained 2-4 weeks apart were examined for neutralizing antibody to coxsackie B 1-6, and echo 4, 6, 7, 9 and 11 viruses. Only eight cases (6.9 per cent) showed a significant change in titer, indicating a virus infection during or shortly before the study. Complement-fixing antibody titers were measured in 126 patients and neutralizing antibodies in 116 patients with idiopathic cardiomyopathy. More patients had complement-fixing antibody titers ⩾ 1 : 4 to coxsackie B and herpes simplex virus than did controls (p > 0.05). Neutralizing antibody titers to coxsackie B 1 and B 3 virus were also higher in patients (p > 0.01 for titers ⩾ 1 : 4 and p > 0.05 for titers ⩾ l : 16). Complement-fixing antibody titers ⩾ 1 : 4 to herpes simplex virus were more frequent (p > 0.05) in hypertrophic cardiomyopathy and those to coxsackie B, herpes simplex and influenza A virus were more frequent in congestive cardiomyopathy. Neutralizing antibody titers were more common to coxsackie B 3 (p < 0.05 for titers of ⩾ 1 : 4) in hypertrophic cardiomyopathy, while in congestive cardiomyopathy they were more common to coxsackie B 1 (p < 0.01 for titers ⩾ 1 : 4 and p < 0.05 for titers ⩾ 1 : 16), to coxsackie B 3 virus (p < 0.001 for titers ⩾ 1 :4 and p < 0.05 for titers ⩾ 1 : 16) and to coxsackie B 5 (p < 0.05 for titers >1 1 : 4 or more) and to echo 6 virus (p < 0.05 for titers ⩾ 1 : 4 and ⩾ 1 : 128). Immunofluorescent study of 61 cases showed no virus antigens in the biopsied myocardium even in patients who had significant changes in neutralizing antibody titers in paired sera. These results suggest a relationship between virus infection and idiopathic cardiomyopathy not only of the congestive type but also of the hypertrophic type. However, they do not provide definite proof of the virus infection theory of the disease.
- 社団法人日本循環器学会の論文
- 1981-03-20
著者
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Kitaura Yasushi
The Third Division Department Of Internal Medicine Osaka Medical College
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Kitaura Yasushi
The Third Department Of Internal Medicine Osaka Medical College
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