Hyperinsulinemia as a Risk Factor for Restenosis After Coronary Balloon Angioplasty

概要

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The present study evaluated whether hyperinsulinemia is a predictor of restenosis after coronary balloon angioplasty in 69 patients who underwent elective coronary balloon angioplasty; patients were excluded if they were known diabetics being treated with insulin. Quantitative coronary angiography was performed before and after angioplasty and at follow-up. Restenosis was defined as the presence of ≥50% stenosis at follow-up. Plasma insulin responses before, 30, 60, and 120 min after 75 g glucose load(OGTT)were measured. Plasma insulin levels were higher in patients with restenosis than in patients without restenosis. Minimal lumen diameter at follow-up was smaller, and percent diameter stenosis at follow-up was higher and late loss was greater in the highest sum of insulin levels during OGTT(Σ insulin)quartile(0.95±0.15 vs 1.47±0.09 mm, p=0.005; 66.3±5.8 vs 40.5±3.3%, p=0.0003; 0.90±0.15 vs 0.49±0.08 mm, p=0.02). Even after adjustment for coronary risk factors and administration of angiotensin converting enzyme inhibitors, the association of hyperinsulinemia with restenosis leads to the conclusion that hyperinsulinemia is a strong risk factor for restenosis.
社団法人日本循環器学会の論文
2001-10-20