Thallium-201 Single Photon Emission Computed Tomography(SPECT) in Patients With Duchenne's Progressive Muscular Dystrophy : A Histopathologic Correlation Study

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概要

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• The pathomorphologic mechanism responsible for abnormal perfusion imaging during thallium-201 myocardial single photon emission computed tomography (^<201>Tl-SPECT) in patients with Duchenne's progressive muscular dystrophy(DMD) was investigated. Hearts from 7 patients with DMD were evaluated histopathologically at autopsy and the results correlated with findings on initial and delayed resting ^<201>Tl-SPECT images. The location of segments with perfusion defects correlated with the histopathologically abnormal segments in the hearts. Both the extent and degree of myocardial fibrosis were severe, especially in the posterolateral segment of the left ventricle. Severe transmural fibrosis and severe fatty infiltration were common in segments with perfusion defects. In areas of redistribution, the degree of fibrosis appeared to be greater than in areas of normal perfusion; and intermuscular edema was prominent. Thus, the dgree and extent of perfusion defects detected by ^<201>Tl-SPECT were compatible with the histopathology. The presence of the redistribution phenomenon may indicate ongoing fibrosis. Initial and delayed resting ^<201>Tl-SPECT images can predict the site and progress of myocardial degeneration in patients with DMD.

• 社団法人日本循環器学会の論文
• 2001-01-20

著者

• Yoshino Hideaki

  Second Department Of Internal Medicine Kyorin University School Of Medicine

• Yoshino Hideaki

  Department Of Cardiology Kyorin University School Of Medicine

• Sakata Konomi

  Second Department of Internal Medicine, Kyorin University School of Medicine

• Sakata Konomi

  Second Department Of Internal Medicine Kyorin University School Of Medicine

• Sakata Konomi

  The Second Department Of Internal Medicine Kyorin University School Of Medicine

• Isshiki Takaaki

  The Department Of Medicine Teikyo University School Of Medicine

• Isshiki Takaaki

  Department Of Cardiology Teikyo University School Of Medicine

• Ishikawa Kyozo

  Second Department Of Internal Medicine Kyorin University School Of Medicine

• Ishikawa Kyozo

  The Second Department Of Internal Medicine Kyorin University School Of Medicine

• Yanagisawa Atsuo

  Second Department Of Internal Medicine Kyorin University School Of Medicine

• Isshiki Takaaki

  Department Of Internal Medicine Teikyo University

• Nishimura Toru

  Second Department of Internal Medicine, Kyorin University School of Medicine

• Sakata Hitomi

  Department of Pathology, Kawaguchi Municipal Medical Center

• Shimoyama Katsuya

  Second Department of Internal Medicine, Kyorin University School of Medicine

• Ishihara Tadayuki

  Neuro-Muscular Center, National Higashi-Saitama Hospital

• ISHIHARA TADAYUKI

  National Higashisaitama Hospital

• Yoshino Hideaki

  Second Department Of Internal Medicine Kyorin University

• Sakata Hitomi

  Department Of Pathology Kawaguchi Municipal Medical Center

• Nishimura Toru

  Second Department Of Internal Medicine Kyorin University School Of Medicine

• Ishikawa Kyozo

  2nd Department Of Internal Medicine Kyorin University

• Shimoyama Katsuya

  Second Department Of Internal Medicine Kyorin University School Of Medicine

• Yanagisawa Atsuo

  The Second Department Of Internal Medicine Kyorin University School Of Medicine

• Yoshino Hideaki

  Second Department Of Internal Medicine Cardiology Kyorin University School Of Medicine

• Sakata Konomi

  Second Department Of Internal Medicine Kyorin University Of Medicine

• Yanagisawa Atsuo

  Second Department of Internal Medicine, Kyorin University School of Medicine

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