Coronary lesion morphology and prognosis in young males with myocardial infarction with or without familial hypercholesterolemia

スポンサーリンク

概要

• 論文の詳細を見る

• The present study examined the angiographic characteristics and prognosis of young males under 40 years of age with acute myocardial infarction (AMI) and familial hypercholesterolemia (FH). The study group was divided into an FH group (n = 16) and a non-FH group (n = 27). Lesion morphology was classified as complex or smooth. Overall 36 patients were followed up for an average of 9.4 years. The frequency of angiographic normal or non-obstructive culprit lesions was significantly higher in the non-FH group (p < 0.01). In contrast, the incidence of complex or totally occlusive lesions was higher in the FH group (p < 0.01). At 10-year follow-up, survival rates from cardiac death (FH 85% vs non-FH 100%, p = 0.06), from AMI (FH 43% vs non-FH 80%, p < 0.05), and from any ischemic event at a new lesion (FH 9% vs non-FH 67%, p < 0.01) were all reduced in the FH group. These results suggest that the mechanism of AMI in young male patients with FH differs from that in similar aged patients without FH, and that the overall prognosis of these patients is less favorable.

• 社団法人日本循環器学会の論文
• 2001-03-20

著者

• Shimizu Masami

  the Second Department of Internal Medicine, Kanazawa University Hospital

• Yamagishi Masakazu

  Japanese Brugada Multicenter Registry By The Minister Of Health Labour And Welfare National Cardiova

• MABUCHI Hiroshi

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University

• Mabuchi Tomohito

  Department of Cardiology, Fukui Prefectural Hospital

• Yasuda Toshihiko

  Division Of Cardiology Ishikawa Prefectural Hospital

• Yasuda Toshihiko

  Ishikawa Prefectural Central Hospital

• Yasuda Toshihiko

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa

• Ino Hidekazu

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa

• Okeie Kazuyasu

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa

• Yamaguchi Masato

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa

• Fujino Noboru

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa

• Fujii Hiroyuki

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa

• Mabuchi Tomohito

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa

• Mizuno Sumio

  Cardiology Division, Fukui Cardiovascular Center

• Okeie Kazuyasu

  The Second Department Of Internal Medicine School Of Medicine Kanazawa University Kanazawa

• Mabuchi Tomohito

  Department Of Cardiology Fukui Prefectural Hospital

• Fujii Hiroyuki

  Komatsu Municipal Hospital

• Fujita Hiromi

  Ohara General Hospital Fukushima Jpn

• Mabuchi Hiroshi

  The Second Department Of Internal Medicine

• Shimizu Masami

  The Second Department Of Internal Medicine School Of Medicine Kanazawa University

• Yamaguchi Masato

  The Second Department Of Internal Medicine Gifu University School Of Medicine

• Yamagishi Masakazu

  Molecular Genetics Of Cardiovascular Disorders Graduate School Of Medical Science Kanazawa Universit

• Itoh Hideki

  Department Of Emergency And Critical Care Medicine Kanazawa University Hospital

• Mabuchi Tomohito

  Molecular Genetics Of Cardiovascular Disorders Division Of Cardiovascular Medicine Graduate School O

• Shimizu Masami

  The Second Department Of Internal Medicine Kanazawa University Hospital

• INO Hidekazu

  the Second Department of Internal Medicine, School of Medicine, Kanazawa University

関連論文

• Experience of appendicular thermal therapy applied to a patient with a left ventricular assist device awaiting heart transplantation
• -0426-EVALUATION OF SYMPATHETIC NERVE ACTIVITY IN HYPERTROPHIC CARDIOMYOPATHY : QUANTITATIVE EVALUATION WITH I-123 MIBG AND Tl-201
• PJ-651 Predictors of the Improvement in Left Ventricular Ejection Fraction in Non-Ischemic Dilated Cardiomyopathy during Beta-Blocker Therapy(PJ109,Heart Failure (Treatment) 3 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanes
• PJ-372 Systemic Vascular Resistance Guided Optimal Drug Selection in Patients with Acute Decompensated Heart Failure : A Validation Study(PJ063,Heart Failure (Treatment) 1 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Ci
• PE-357 Does Preoperative Left Atrial Dilatation Predict Adverse Events after Aortic Valve Replacement?(PE060,Valvular Heart Disease (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-254 "Cardiac Anemia" is an Independent Predictor of Prognosis in Patients with Non-Ischemic Chronic Heart Failure(PE043,Heart Failure (Biomarker) 1 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-034 Negative Impact of Cardio-renal Anemia Syndrome on Beta-blocker Tolerance and Subsequent Major Adverse Cardiac Events in Chronic Heart Failure(PE006,Kidney/Renal Circulation/CKD 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of T
• OE-389 Clinical Phenotype of Japanese LQT1 Form of Congenital Long QT Syndrome by Location and Coding Type From Japanese Multicenter Registry(Arrhythmia, diagnosis/Pathophysiology/EPS(02)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of
• FRS-149 Mutation Site-Specific Differences in Arrhythmic Risk and Sensitivity to Sympathetic Stimulation in Japanese Families with Congenital LQT1 Syndrome(Sudden Cardiac Death (A) : FRS18)(Featured Research Session (English))
• Hemodynamic and Echocardiographic Evaluation of Orthotopic Heart Transplantation With the Modified Bicaval Anastomosis Technique
• 2 Present Strategy for the Treatment of Profound Heart Failure : Long-term Support by Left Ventricular Assist Systems and Heart Transplantation(Therapeutic Strategy for Severe Heart Failure-From LVAD to Heart Transplantation-,Symposium 11 (SY-11) (H),The
• OE-352 The Preoperative Cardio-Renal-Anemia-Syndrome and Myocardial Fibrosis Have Negative Impact on Survival and Myocardial Recovery After Left Ventricular Assist Device Implantation(Heart failure, clinical(04)(M),Oral Presentation(English),The 72nd Annu
• OE-157 Clinical course and outcome of heart transplant recipients : single center' s experience at National Cardiovascular Center(Transplantation/LVAD (IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• 4 Cardiac rehabilitation in the management of patients with end-stage heart failure(Symposium 16 (SY-16) (H) Cardiac Rehabilitation : Innovative Approach to Improve Patient Care,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulatio
• 4 Long-term Use of Left Ventricular Assist System as a Bridge to Heart Transplant : Superior Survival Rate to REMATCH Trial(Symposium 8 (SY-08) (M) New Strategies for Management of Severe Heart Failure with New Devices and Surgery,Special Program,The 72nd
• PE-502 Impact of Acceleration of Post-prandial Remnant Lipoprotein Clearance in Autosomal Recessive Hypercholesterolemia (ARH)(PE084,Lipid Disorders 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
• Effects of Glucose Abnormalities on In-hospital Outcome After Coronary Intervention for Acute Myocardial Infarction (Acute Myocardial Infarction, Clinical (Pathophysiology) 5 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Strategy for treating elderly Japanese with hypercholesterolemia
• PJ-767 Combined Prognostic Utility of White Blood Cell Count, Plasma Glucose Level, and Glomerular Filtration Rate in Acute Myocardial Infarction(PJ129,Myocardial Ischemia-reperfusion (Basic, Clinical) (IHD),Poster Session (Japanese),The 73rd Annual Scien
• PJ-178 Gender Differences in Outcomes after Primary Coronary Intervention for Acute Myocardial Infarction(Acute myocardial infarction, clinical (pathophysiology)-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Difference between Fasting and Nonfasting Triglyceridemia ; the Influence of Waist Circumference
• PJ-540 Risk of Surgery after Coronary Drug-Eluting Stent Implantation(PJ091,Coronary Revascularization, PCI (DES) 3 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-757 Predictors of the Degree of Distal Embolism Following Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome(Acute coronary syndrome, basic/ clinical(06)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the J
• Telmisartan treatment decreases Visceral Fat Accumulation and improves Serum Levels of Adiponectin and Vascular Inflammation Markers in Japanese Hypertensive Patients.
• Effect of Walking with a Pedometer on Serum Lipid and Adiponectin Levels in Japanese Middle-aged Men
• OE-354 Automated Function Imaging would be Correlated with Systolic and Diastolic Parameter of Conventional Echocardiography and Catheterization(Heart failure, clinical(04)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese C
• DPJ-054 Is Cardiac Rehabilitation Unnecessary in Low Prognostic Risk Patients with Acute Myocardial Infarction in the Primary Intervention Era?(DPJ09,Exercise Test/Cardiac Rehabilitation (H),Digital Poster Session (Japanese),The 73rd Annual Scientific Mee
• 2 Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome (Japan-ACS)(Late Breaking Clinical Trials I,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PE-396 Impact of New Insights of Lipoprotein Metabolism in Autosomal Recessive Hypercholesterolemia : A Stable Isotope Kinetic Study in Vivo(PE067,Lipid Disorders 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulatio
• Gene mutations in adult Japanese patients with dilated cardiomyopathy
• Coronary lesion morphology and prognosis in young males with myocardial infarction with or without familial hypercholesterolemia
• Diagnostic usefulness of the post-exercise systolic blood pressure response for the detection of coronary artery disease in patients with diabetes mellitus
• PE-103 Clinical Phenotype of Japanese LQT3 Form of Congenital Long QT Syndrome by Location of Mutation from Japanese Multicenter Registry(PE018,Arrhythmia, Others (Clinical/Pathophysiology) (A),Poster Session (English),The 73rd Annual Scientific Meeting o
• FRS-117 Clinical and Electrocardiographic Characteristics of Japanese Probands with Brugada Syndrome with an SCN5A Mutation from Japanese Multicenter Registry(FRS24,Novel Mechanisms of Ventricular Arrhythmia (A),Featured Research Session (English),The 73r
• PJ-208 Impact of Frameshift Mutation and Nonsense-mediated mRNA Decay on Clinical Phenotype in LQT2 Form of Congenital Long QT Syndrome(Arrhythmia,diagnosis/Pathophysiology/EPS(13)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japa
• Role of Echocardiography in Assessing Pregnant Women With and Without Heart Disease
• PE-060 Echocardiographic Signs of Pericardial Constriction as Predictors of Maternal Heart Failure in pregnant Women after Open Heart Surgery(Echo/Doppler-08, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• IS094 TFPI Competes With LPL on Endothelium : A Possible Mechanism of Low HDL.c in Atherosclerosis
• Distribution of QTc Values and Prevalence of Short QT Syndrome in the Japanese Population (ECG/Body Surface Potential Mapping/Holter 6 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Gene Mutations in Patients with Hypertrophic Cardiomyopathy Showing Mild Left Ventricular Hypertrophy(Cardiomyopathy, Clinical 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Differences in Diagnostic Value of Classic Electrocardiographic Voltage Criteria for Hypertrophic Cardiomyopathy in a Genotyped Population(Cardiomyopathy, Clinical 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Ankyrin-B Gene Mutation is a Rare Cause of Long QT Syndrome in Japan(Arrhythmia, Basic 1 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Long-Term Course of Patients with Cardiomyopathy Associated with Phospholamban Gene Mutations(Cardiomyopathy, Clinical 8 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Early Development of Dilated Cardiomyopathy in Subjects with Hypertrophic Cardiomyopathy Caused by Mutations of the Thin Filament Genes(Cardiomyopathy, Clinical 7 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Angiotensin II Type 1 Receptor A/C1166 Gene Polymorphism and Left Ventricular Systolic Dysfunction in Hypertrophic Cardiomyopathy with Sarcomere Gene Mutations(Cardiomyopathy, Clinical 7 (M), The 69th Annual Scientific Meeting of the Japanese Circulation
• Impact of Bundle-Branch Block on Clinical Manifestation in Patients with Hypertrophic Cardiomyopathy : Analyses Based on Molecular Genetic Diagnoses(Cardiomyopathy, Clinical 6 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• OE-155 Reduced Left Ventricular Torsion with Two-Dimensional Speckle Tracking Echocardiography would Predict Acute Rejection in Heart Transplant Recipients.(Transplantation/LVAD (IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Ja
• PJ-260 Triglyceride-rich Lipoprotein Cholesterol Abnormalities of Familial Hypercholesterolemia : An Ultracentrifugation Analysis(PJ044,Atherosclerosis (Clinical/Diagnosis) 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japane
• PE-093 The Carotid Intima-media Thickness of Young Familial Hypercholesterolemia (FH) is Greater than Non-FH Littermates(PE016,Atherosclerosis (Clinical/Diagnosis) (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulati
• DPE-029 Clinical Impact of Heterozygous Carrier of Autosomal Recessive Hypercholesterolemia on Asymptomatic Hyperlipidemic Patients : Evidence from Familial Gene Analysis(DPE05,Lipid Disorders (H),Digital Poster Session (English),The 73rd Annual Scientifi
• OE-154 Cardiac Sarcoidosis in Japanese Heart Transplant Patients(Transplantation/LVAD (IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• The role of a common TNNT2 polymorphism in cardiac hypertrophy
• FRS-128 Mutations in Phospholamban Gene Cause Hypertrophic and Dilated Cardiomyopathy(Myocardial Disease (M) : FRS16)(Featured Research Session (English))
• PJ-443 Impact of Primary Aldosteronism on Occurrence of Atrial Fibrillation and Cerebral Events(PJ075,Hypertension, Clinical 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Scintigraphic evaluation of regression of abnormal Q waves in myocardial infarction
• Prevalence and Onset of Hypertrophic Cardiomyopathy Caused by Thin Filament Gene Mutations(Cardiomyopathy, Clinical 6 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-425 Early Development of Dilated Cardiomyopathy in Subjects with Mutations in the Cardiac Troponin Complex Genes(Cardiomyopathy, Clinical 5 (M) : PJ71)(Poster Session (Japanese))
• OJ-335 PRKAR1A Gene Mutation in Patients with Cardiac Myxoma(Valvular Heart Disease/Pericarditis/Cardiac Tumor 2 (M) : OJ40)(Oral Presentation (Japanese))
• Alterations in Echocardiographic Tissue Characterization in Patients with Cardiac Troponin I Gene Mutation a Possible Indicator of Preclinical Hypertrophic Cardiomyopathy
• Cardiac Actin and Alpha-Tropomyosin Genes Are Associated with Neither Hypertrophic Nor Dilated Cardiomyopathy in Patients from Hokuriku District in Japan
• Systolic dysfunction and blood pressure responses to supine exercise in patients with hypertrophic cardiomyopathy
• Left ventricular dysfunction and dilatation in elderly patients with hypertrophic cardiomyopathy associated with a novel missense mutation in MyBP-C gene
• -209- IMPAIRED LEFT VENTRICULAR DIASTOLIC FUNCTION DURING VASOSPASM STUDIED BY PULSED DOPPLER ECHOCARDIOGRAPHY : Cardiac : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -155- RECOGNITION OF MITRAL VALVE PROLAPSE WITH SPECIAL REFERENCE TO THE CONFIGURARION AND REGURGITATION OF MITRAL VALVE : Myocardial Infarction, Valvular Heart Disease : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JA
• Perfusable tissue index obtained by positron emission tomography as a marker of myocardial viability in patients with ischemic ventricular dysfunction
• Quantitative Assessment of Wall Motion Using Myocardial Strain
• Myocardial damage in the presence of severe mitral regurgitation can be assessed by systolic myocardial velocity gradient
• Propagation of Mitral Valve Closure Flow to the Pulmonary Vein : Its Clinical Relevance to Left Atrial Compliance in Patients With Atrial Fibrillation
• Probucol-Induced Long QT Syndrome Associated with a Novel Missense Mutation M124T in the N Terminus of HERG
• Long QT Syndrome Mutations in Different Sites of HERG Elicit a Variety of Functional Changes
• Double Missense Mutations (D611Y in KCNQ1 and D609G in HERG) in a Japanese Family with Long QT Syndrome
• Arrhythmias in patients with Brugada-type electrocardiographic findings
• SERIAL ELECTROCARDIOGRAPHIC AND ANGIOGRAPHIC CHANGES OF PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY
• FUNCTIONAL LIMITATION OF RECRUITABLE COLLATERALS IN HUMAN SUBJECTS : ST Segment Deviation on Intracoronary Electrocardiogram during Transient Coronary Occlusion Induced by Balloon Inflation
• PRELOAD DEPENDENCY OF LEFT ATRIAL PUMP FUNCTION IN HYPERTROPHIC CARDIOMYOPATHY
• INCREASE IN LEFT VENTRICULAR CHAMBER STIFFNESS IN PATIENTS WITH NON-INSULIN DEPENDENT DIABETES MELLITUS
• -412-COMPARISON BETWEEN PATIENTS OF HYPERTROPHIC CARDIOMYOPATHY WITH THE CLINICAL PROFILE OF DILATED CARDIOMYOPATHY AND PATIENTS OF DILATED CARDIOMYOPATHY : Cardiomyopathy : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF TH
• IS130 Dipylidamole induced stunning continues for at least one hour in patients with coronary artery disease : Evaluation with quantitative gated SPECT
• Clinical features and prognosis of Japanese patients with anomalous origin of the coronary artery
• Effects of hepatic lipase gene promoter nucleotide variations on serum HDL cholesterol concentration in the general Japanese population
• Usefulness of Acoustic Densitometry Method for Detection of Myocardial Changes in Preclinical Patients with Hypertrophic Cardiomyopathy
• Right Ventricular Metastasis From a Primary Cervical Carcinoma
• Acute urinary retention as an unusual manifestation of aseptic meningitis
• Association between Single Nucleotide Polymorphisms (SNPs) of Cardiac Potassium Channel Genes and Drug-Induced Long QT Syndrome in Japanese
• A Novel Mutation (lnt21DSG+1A) in the MyBP-C Gene Shows Hypertrophic Cardiomyopathy with a High Degree of Penetrance in Adult Patients
• Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2008) : Digest Version
• Diagnostic Values of Abnormal Q Waves for Hypertrophic Cardiomyopathy Based on the Genetic Information
• QT Variables in Preclinical Patients with Hypertrophic Cardiomyopathy
• QT Variables in Various Genotyped Patients with Hypertrophic Cardiomyopathy
• Mitochondrial DNA Mutations in Hypertrophic Cardiomyopathy
• Frequency of Asymmetric Septal Hypertrophy in Patients with Hypertrophic Cardiomyopathy : Difference in Genotypes
• Differences in Diagnostic Values of Abnormal Q Waves between Hypertrophic Cardiomyopathy with a cTnl Gene Mutation and MyBP-C Gene Mutations
• Spontaneous Development of Left Ventricular Aneurysm in a Patient With Untreated Cardiac Sarcoidosis
• Acute urinary retention as an unusual manifestation of aseptic meningitis
• Impact of Renin-Angiotensin System Polymorphisms on Development of Systolic Dysfunction in Hypertrophic Cardiomyopathy : Evidence From a Study of Genotyped Patients
• Efficacy of Out-Patient Cardiac Rehabilitation in Low Prognostic Risk Patients After Acute Myocardial Infarction in Primary Intervention Era
• Unusual biatrial thrombus in mitral stenosis
• Emergent thoracic aortic angioplasty and stenting for middle aortic syndrome in non-specific aortitis
• Clinical and Genetic Features of Japanese Patient with Congenital Long QT Syndrome
• Hereditary angioedema complicated with chronic renal failure: report of sibling cases.

もっと見る 閉じる

スポンサーリンク