Increased Plasma Soluble Intercellular Adhesion Molecule-1 Levels in Patients With Acute Myocardial Infarction
スポンサーリンク
概要
- 論文の詳細を見る
Intercellular adhesion molecule-1 (ICAM-1) is a major ligand for 2 members of the CD18 family of leukocyte integrin adhesion molecules and mediates adhesion between leukocytes and stimulated endothelial cells. We examined plasma soluble ICAM-1 (sICAM-1) levels in 30 patients with acute myocardial infarction (AMI) within 6 h of symptom onset, 21 patients with unstable angina (UA), 35 patients with stable exertional angina (SEA) and 21 control subjects. Plasma sICAM-1 levels (ng/ml) were significantly higher in both the acute and chronic phases of AMI and in the UA group than in the SEA and the control groups (195±14, 198±16 in the acute and chronic phases of AMI, 188±11 in the UA group vs 142±7 in the SEA group, 141±10 in the control group, p<0.01). Plasma sICAM-1 levels were significantly higher in AMI patients when preceded by unstable angina than when not preceded by unstable angina at any point over the time course except 1 week after admission (p<0.01 vs admission, 12 h, 2 days, 3 days, 5 days, 2 weeks, 3 weeks. p<0.05 vs 24 h). These results suggest that the increase in sICAM-1 is associated with repeated episodes of myocardial ischemia and reperfusion not leading to myocardial necrosis. The increase in sICAM-1 may play an important role as an inflammatory component in the pathogenesis of the ischemic myocardium.
- 社団法人日本循環器学会の論文
- 1997-08-20
著者
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Sakamoto Tomohiro
Division Of Cardiology Saiseikai Kumamoto Hospital Cardiovascular Center
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Ogawa Hisao
Division of Cardiovascular medicine Kumamoto University Graduate School of Medical Sciences
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Kamijikkoku Shuichi
Division Of Cardiology Kumamoto Red-cross Hospital
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Yasue Hirofumi
Division of Cardiology, Kumamoto Aging Research Institute
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Tayama Shinji
Division of Cardiology, Cardiovascular Center, Saiseikai Kumamoto Hospital
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Honda Takashi
Division of Cardiology, Cardiovascular Center, Saiseikai Kumamoto Hospital
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Yasue Hirofumi
Division Of Cardiology Kumamoto University School Of Medicine
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Yasue H
Kumamoto Univ. School Of Medicine
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Koshi Shuichi
Cosmo Health Care Center
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Hanawa Takao
Division Of Cardiology Cardiovascular Center Saiseikai Kumamoto Hospital
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Honda Toshihiro
Cardiovascular Center Saiseikai Kumamoto Hospital
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Suefuji Hisakazu
Division of Cardiology, Kumamoto University School of Medicine
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Soejima Hirofumi
Division of Cardiology, Kumamoto University School of Medicine
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Kaikita Koichi
Division of Cardiology, Kumamoto University School of Medicine
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Miyao Yuji
Division of Cardiology, Kumamoto University School of Medicine
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Hayasaki Kazuya
Division of Cardiology, Saiseikai Kumamoto Hospital
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Yasue Hirofumi
Division Of Cardiology Kumamoto University Medical School
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Miyao Yuji
Division Of Cardiovascular Center Kumamoto National Hospita
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Hanawa Takao
Division Of Preventive Cardiology National Cardiovascular Center
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Yasue Hirofumi
Division Of Cardilogy Kumamoto University School Of Medicine
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Ogawa Hisao
Division Of Cardiology Health Insurance Hitoyoshi General Hospital
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Tanaka Hiromitsu
Department Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine
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Sakamoto Tomohiro
Division Of Cardiology Cardiovascular Center Saiseikai Kumamoto Hospital
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Hayasaki Kazuya
Cardiovascular Center Saiseikai Kumamoto Hospital
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Hayasaki Kazuya
Division Of Cardiology Saiseikai Kumamoto Hospital
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Hayasaki Kazuya
Saiseikai Kumamoto Hospital
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Hayasaki Kazuya
The Heart Institute Japan Tokyo Women's Medical College
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Suefuji Hisakazu
Division Of Cardovascular Center Kumamoto National Hospital
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Yasue Hirofumi
Division Of Cardiology School Of Medicine Kumamoto University
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Yasue Hirofumi
Department Of Cardiology Kumamoto City Hospital
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Yasue Hirofumi
Division Of Cardiovascular Medicine Kumamoto Kinoh Hospital Kumamoto Aging Research Institute
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Tayama Shinji
Division Of Cardiology Cardiovascular Center Saiseikai Kumamoto Hospital
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Honda Takashi
Division Of Cardiology Saiseikai Kumamoto Hospital
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Soejima Hirofumi
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kumamoto University
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