Circadian Variation in Plasma Levels of Free-Form Tissue Factor Pathway Inhibitor Antigen in Patients With Coronary Spastic Angina
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概要
- 論文の詳細を見る
Tissue factor pathway inhibitor(TFPI)is known to inhibit the initial reaction in the tissue factor-mediated coagulation pathway.We measured plasma free-form TFPI antigen levels and monitored 24-h Holter recordings at 06.00, 14.00 and 22.00 h in 15 patients with coronary spastic angina, 13, patients with stable exertional angina, and 11 control subjects.There was a significant circadian variation in plasma free-form TFPI antigen levels in patients with coronary spastic angina(25.8±2.0 ng/ml at 06.00h, 21.1±1.6 ng/ml at 14.00 h, and 20.2±1.4 ng/ml at 22.00 h;p<0.01).Furthermore, free-form TFPI antigen levels at 06.00 h were significantly higher in coronary spastic angina patients than in patients with stable exertional angina or control subjects(p<0.01).Free-form TFPI antigen levels increased after the ischemic attacks in coronary spastic angina(p<0.01).This circadian variation correlated with the frequency of attacks, with the peak level occurring between midnight to early morning in patients with coronary spastic angina.
- 社団法人日本循環器学会の論文
- 1998-05-20
著者
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Ogawa Hisao
Division of Cardiovascular medicine Kumamoto University Graduate School of Medical Sciences
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Yasue Hirofumi
Division of Cardiology, Kumamoto Aging Research Institute
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Yasue Hirofumi
Division Of Cardiology Kumamoto University School Of Medicine
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Yasue H
Kumamoto Univ. School Of Medicine
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Suefuji Hisakazu
Division of Cardiology, Kumamoto University School of Medicine
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Soejima Hirofumi
Division of Cardiology, Kumamoto University School of Medicine
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Nishiyama Koichi
Division of Cardiology, Kumamoto University School of Medicine
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Misumi Kenji
Division of Cardiology, Kumamoto University School of Medicine
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Takazoe Keiji
Division of Cardiology, Kumamoto University School of Medicine
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Kugiyama Kiyotaka
Division of Cardiology, Kumamoto University School of Medicine
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Tsuji Ichiro
The Chemo-Sero-Therapeutic Research Insitute
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Kumeda Kousuke
The Chemo-Sero-Therapeutic Research Insitute
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Yokote Hiroyuki
The Chemo-Sero-Therapeutic Research Institute
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Yasue Hirofumi
Division Of Cardiology Kumamoto University Medical School
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Nishiyama Koichi
Department Of Cardiovascular And Renal Medicine Saga University Faculty Of Medicine
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Yasue Hirofumi
Division Of Cardilogy Kumamoto University School Of Medicine
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Misumi Kenji
Division Of Cardiology Kumamoto University School Of Medicine
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Tsuji Ichiro
The Chemo-sero-therapeutic Research Institute Kumamoto
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Takazoe Keiji
Division Of Cardiology Kumamoto Central Hospital
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Kumeda Kousuke
The Chemo-sero-therapeutic Research Institute Kumamoto
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Ogawa Hisao
Division Of Cardiology Health Insurance Hitoyoshi General Hospital
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Nakao Koichi
Department Of Cardiology Saiseikai Kumamoto Hospital Cardiovascular Center
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Soejima Hirofumi
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Suefuji Hisakazu
Division Of Cardovascular Center Kumamoto National Hospital
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Yasue Hirofumi
Division Of Cardiology School Of Medicine Kumamoto University
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Yasue Hirofumi
Department Of Cardiology Kumamoto City Hospital
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Yasue Hirofumi
Division Of Cardiovascular Medicine Kumamoto Kinoh Hospital Kumamoto Aging Research Institute
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Nishiyama Koichi
Division Of Cardiology Saiseikai Kumamoto Hospital Cardiovascular Center
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Kugiyama Kiyotaka
Division Of Cardiology And Department Of Radiology Kumamoto University Hospital
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Nakao Koichi
Division Of Cardiology Saiseikai Kumamoto Hospital
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Kugiyama Kiyotaka
The First Department Of Internal Medicine Kumamoto University Medical School
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Kugiyama Kiyotaka
The Second Department Of Internal Medicine Interdisciplinary Graduate School Of Medicine And Enginee
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Tanoue Kichi
Division Of Cardiology Kumamoto Central Hospital
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Nishiyama Koichi
Department Of Physiological Chemistry And Etabolism Graduate School Of Medicine The University Of To
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Node Koichi
Cardiovascular Center Saiseikai Kumamoto Hospital
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Soejima Hirofumi
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kumamoto University
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