Relationship Between Left Ventricular Diastolic Function at Rest and Exercise Capacity ira Patients who Have Suffered a Previous Myocardial Infarction

概要

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To assess whether left ventricular (LV) diastolic function is a determinant of exercise capacity in patients who have suffered a previous myocardial infarction (MI), we investigated the relationship between maximum exercise duration and resting LV diastolic function in 65 MI patients. Each patient underwent both a symptom-limited exercise test and LV biplane angiography with simultaneous high-fidelity pressure measurements. LV relaxation was assessed by the time constants (T_<1/e> and T_<1/2>) of isovolumic pressure decay, and LV diastolic distensibility was assessed by the LV end-diastolic volume (V) index-pressure (P) ratio. The time constants of relaxation did not correlate with maximum exercise capacity (r=-0.19 for T_<1/e>, NS; r=-0.17 for T_<1/2>, NS). LV diastolic distensibility also did not correlate with exercise capacity (r=-0.08, NS). These results suggest that the resting LV diastolic dysfunction is unlikely to be the principal cause of exercise intolerance in MI patients without congestive heart failure.
社団法人日本循環器学会の論文
1997-03-20