Angiographic Study of Mutant Tissue-Type Plasminogen Activator Versus Urokinase for Acute Myocardial Infarction
スポンサーリンク
概要
- 論文の詳細を見る
The effects and problems of intravenous thrombolytic therapy with a bolus injection of mutant tissue plasminogen activator (t-PA) were investigated in 34 patients with first acute myocardial infarction (AMI). In contrast, 114 patients were selected from 1, 003 patients with AMI for treatment using intravenous infusion urokinase (UK). Angiography of these 148 patients revealed a complete occlusion of infarct-related artery with no clear contraindications to the study treatment. With the exception of thrombolysis in myocardial infarction (TIMI-3) recanalization 60 min after a bolus injection of mutant t-PA, the patients were given intracoronary UK in addition to mutant t-PA. The study comparisons were assessed using the following criteria: (1) 60-min assessment of recanalization rates, mutant t-PA vs UK; (2) time interval from initiation of thrombolysis to recanalization, mutant t-PA vs UK; (3) angiographic reocclusion rates within 1 month, mutant t-PA alone vs UK vs mutant t-PA plus UK; and (4) intracerebral hemorrhage rates, mutant t-PA alone vs UK vs mutant t-PA plus UK. There were no significant differences in the recanalization rates between mutant t-PA and UK, but there was a significant reduction in the time to recanalization with mutant t-PA (31.8±12.7 min) compared with UK (56.5±6.3 min). There was a significant difference in the reocclusion rates among the 3 treatment groups (20% mutant t-PA alone vs 4% UK vs 0% mutant t-PA plus UK). On the other hand, no significant differences in intracerebral hemorrhage rates among the 3 treatments were observed. In conclusion, thrombolytic therapy with a bolus injection of mutant t-PA achieved more rapid recanalization, but treatment with mutant t-PA led to a high-rate of reocclusion.
- 社団法人日本循環器学会の論文
- 1998-01-20
著者
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Nagao Ken
Department of Cardiology, Nihon University Surugadai Hospital
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Watanabe Ikuyoshi
Department of Cardiology, Nihon University Surugadai Hospital
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Kanmatsuse Katsuo
Department of Cardiology, Nihon University Surugadai Hospital
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Watanabe Ikuyoshi
Department Of Cardiology Nihon University Surugadai Hospital
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Watanabe Ikuyoshi
Second Department Of Internal Medicine Nihon University School Of Medicine
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Arima Ken
Department of Internal Medicine, Division of Cardio-Vascular Medicine, Kurume University
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Arima Ken
Sos-kanto Investigators
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Arima Ken
Department Of Cardiology Surugadai Nihon University Hospital
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Yamashita Makoto
Department of Cardiology, Surugadai Nihon university Hospital
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Oiwa Kouji
Department Of Cardiology Yokohama-chuou Hospital
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Satou Kazuyoshi
Department Of Cardiology Surugadai Nihon University Hospital
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Ooiwa Koji
Department of Cardiology, Surugadai Nihon University Hospital
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Kanmatsuse Katsuo
Department Of Cardiology Nihon University Hospital
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KANMATSUSE Katsuo
Surugadai Nihon University Hospital
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Yamashita Makoto
The Department Of Cardiology Surugadai Nihon University Hospital
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Yamashita Makoto
Department Of Applied Physics Osaka University
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Ooiwa Koji
Department Of Cardiology Yokohama-chuou Hospital
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Nagao Ken
Department Of Cardiology Cardiopulmonary Resuscitation And Emergency Cardiovascular Care Surugadai N
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Kanmatsuse Katsuo
Department Of Cardiology
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Ooiwa Koji
Department Of Cardiology Yokohama Social Insurance Central Hospital
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Nagao Ken
Department Of Cardiology Resuscitation And Emergency Cardiovascular Care Surugadai Nihon University
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Yamashita Makoto
Department Of Applied Chemistry Faculty Of Science And Engineering Chuo University
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