Mechanism for the Cardioprotective Effects of the Calcium Channel Blocker Clentiazem During Ischemia and Reperfusion
スポンサーリンク
概要
- 論文の詳細を見る
To elucidate whether or not Ca channel blockers have an intrinsic benefit that cannot be attributed to the reduction of Ca^<2+> entry by pretreatment, time-averaged intracellular Ca^<2+> concentration([Ca^<2+>]_i)and energy-related phosphates were measured in isolated ferret hearts using nulear magnetic resonance. In the drug-free ischemic group, [Ca^<2+>]_i increased significantly during 30 min of global ischemia at 30℃ and during 0-5 min of reperfusion. After 30 min of reperfusion, isovolumic left ventricular developed pressure recovered only to 63±7% of the pre-ischemic level(mean±SEM;N=5). Pretreatment with the Ca channel blocker clentiazem(10^<-7> mol/L)itself depressed developed pressure by 53±9%. In the clentiazem group, [Ca^<2+>]_i showed no significant changes during ischemia or reperfusion. Recovery of developed pressure(87±8% of untreated level)was significantly higher than in the non-treated group(p<0.05). Nevertheless, when the negative inotropism of clentiazem was offset by increasing [Ca]_o from 2 to 3 mmol/L, no beneficial effects of clentiazem were observed;[Ca^<2+>]_i increased significantly during 0-5 min of reperfusion, and developed pressure recovered only 60±7% of untreated level. These results indicate that reduction of Ca^<2+> entry from the extracellular space to the myocyte, as reflected by negative inotropism during pretreatment, is required for clentiazem to protect myocardium in a model of global ischemia and reperfusion.
- 社団法人日本循環器学会の論文
- 1998-07-20
著者
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Koretsune Yukihiro
Osaka National Hospital
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Koretsune Yukihiro
Division Of Cardiology National Hospital Organization Osaka National Hospital
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Koretsune Yukihiro
心臓血管研究所
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Koretsune Yukihiro
大阪大学 医学系研究科循環器内科学
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Koretsune Yukihiro
Cardiovascular Division Osaka National Hospital
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Kusuoka H
Osaka National Hospital
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Kusuoka Hideo
大阪大学 医系研究 核医画像診断
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Kusuoka Hideo
Division Of Cardiology National Hospital Organization Osaka National Hospital
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Kusuoka Hideo
Institution For Clinical Research Osaka National Hospital
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Marban Eduardo
Division Of Cardiology Department Of Medicine The Johns Hopkins University School Of Medicine
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Koretsune Yukihiro
Department of Cardiology, National Hospital Organization Osaka National Hospital
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KUSUOKA Hideo
HK is currently at Osaka National Hospital
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Kataiwa Hideaki
Department Of Cardiology National Hospital Organization Osaka National Hospital
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Corretti Mary
Division of Cardiology, Department of Medicine, University of Maryland School of Medicine
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Kusuoka Hideo
Division Of Tracer Kinetics Biomedical Research Canter Osaka University Medical School
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Kusuoka Hideo
First Dept. Of Midicine Osaka Univ. Medical School
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Koretsune Yukihiro
National Mie Chuo Hospital
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Koretsune Yukihiro
Departments Of Cardiology National Osaka Hospital
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Corretti Mary
Division Of Cardiology Department Of Medicine University Of Maryland School Of Medicine
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Kusuoka Hideo
Institute For Clinical Research Osaka National Hospital
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Eduardo Marban
Div Of Cardiology The Johns Hopkins Medical Institutions
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Kusuoka Hideo
First Dpt. Of Medicine Osaka University Medical School
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Kusuoka Hideo
First Dept. Of Medicine Osaka University Medical School
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Koretsune Yukihiro
Department Of Cardiology Osaka National Hospital
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Kataiwa Hideaki
Division Of Cardiology National Hospital Organization Osaka National Hospital
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