Effect of Preischemic Catecholamine Treatment on Ischemia-Reperfusion Injury of the Myocardium : Subtype, Dose, and Temperature Dependency
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概要
- 論文の詳細を見る
Preischemic adrenergic stimulation may affect postischemic cardiac function. Using an isolated working heart model, we investigated the effects of preischemic catecholamine treatment on postischemic recovery. Hearts from Wistar rats were perfused in working mode for 20 min, in Langendorff mode for 15 min, and again in working mode for 20 min(W2). Hearts were treated with isoproterenol(8.0 and 40.0 nmol/L), phenylephrine(0.06, 0.30, and 1.50 μmol/L), or epinephrine(16 and 80 nmol/L)during the W2 period and then arrested with St Thomas' Hospital cardioplegic solution(STH)and subjected to global ischemia(37℃ or 20℃), followed by reperfusion. At 37℃, isoproterenol had a beneficial effect at the lower dose but a harmful effect at the higher dose;phenylephrine and epinephrine had a harmful effect at all doses. At 20℃, isoproterenol and epinephrine had a harmful effect at a high dose;phenylephrine had no harmful effect at any dose. In a separate study, the influence of calcium modulators(diltiazem and ryanodine, added in the STH)on the catecholamine effect was investigated. The harmful effect of preischemic treatment with isoproterenol(24.0 nmol/L)or phenylephrine(0.9 μmol/L)was abolished by the calcium modulators. Thus, preischemic β-adrenergic or α+β-adrenergic stimulation has a deleterious effect on postischemic recovery of the myocardium. The effect could be altered depending on the subtype and dose of catecholamine and the ischemic temperature. Intracellular calcium movement could be involved in the mechanism responsible for the harmful effect of preischemic catecholamine treatment.
- 社団法人日本循環器学会の論文
- 1998-06-20
著者
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Yamamoto Fumio
Department of Cardiovascular Surgery, National Cardiovascular Center
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OKA TAKAHIRO
Second Department of Surgery, Kyoto Prefectural University of Medicine
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Shimada Yasuyuki
Second Department Of Surgery Kyoto Prefectural University Of Medicine
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Yamamoto Hiroshi
First Depatment Of Internal Medicine Kobe University School Of Medicine
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Oka Takahiro
Second Department Of Surgery Kyoto Prefectural University Of Medicine
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Yamamoto Fumio
Department Of Cardiovascular Surgery Akita University School Of Medicine
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Yamamoto Fumio
Department Of Cardiovascular Surgery Akita University Medical School
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Yamamoto Hiroshi
First Department Of Surgery Asahikawa Medical College
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Yamamoto Hiroshi
First Department of Internal Medicine, Shinshu University School of Medicine
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Yamamoto Fumio
Department of Applied Chemistry, Faculty of Engineering, Osaka City University
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