Preventive Effects of Angiotensin-Converting Enzyme Inhibitors on Nitrate Tolerance During Continuous Transdermal Application of Nitroglycerin in Patients With Chronic Heart Failure
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概要
- 論文の詳細を見る
This study was designed to investigate the effect of angiotensin-converting enzyme(ACE)inhibitors with and without a sulfhydryl group on intracellular production of cGMP, forearm blood flow, and neurohormonal factors during continuous transdermal application of nitroglycerin in patients with chronic heart failure.Platelet cGMP level andcforearm blood flow were measured before and 5 min after sublingual administration of nitroglycerin(NTG)in 20 patients with chronic heart failure during the following 4 phases:(1)baseline phase;(2)NTG phase(1 week after NTG tape 10 mg/day);(3)CPT phase(1 week after both captopril 37.5 mg/day and NTG tape 10 mg/day);and(4)ENL phase(1 week after both enalapril 5 mg/day and NTG tape 10 mg/day).The platelet GMP level before sublingual NTG and forearm blood flow were significantly higher during the 3 phases with NTG tape than during the control phase.The percent increases in platelet cGMP level and forearm blood flow after sublingual NTG were significantly lower during the NTG phases than during the baseline phase.In contrast, concomitant application of ACE inhibitors maintained the percent increase in plateler cGMP level and forearm blood flow.These results indicate that concomitant therapy with ACE inhibitors may be helpful in preventing the attenuation of intracellular cGMP production in patients with chronic heart failure during continuous transdermal application of NTG.
- 社団法人日本循環器学会の論文
- 1998-04-20
著者
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OHTSUKA Sadanori
Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Scie
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Sugishita Yasuro
Tsukuba Memorial Hospital
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Sugishita Yasuro
Cardiovascular Division, Departments of Medicine, Institute of Clinical Medicine, University of Tsuk
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Watanabe Hideki
Department Of Cardiology Kinu Medical Association Hospital
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Sugishita Yasuro
Department Of Medicine Tsukuba Memorial Hospital
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Ohtsuka Sadanori
Cardiovascular Division Institute Of Clinical Medicine Graduate School Of Comprehensive Human Scienc
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Ohtsuka Sadanori
Department Of Internal Medicine Institute Of Clinical Medicien University Of Taukuba
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Ohtsuka Sadanori
Cardiovascular Division Department Of Internal Medicine Institute Of Clinical Medicine University Of
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Sugishita Yasuro
The Cardiovascular Division Department Of Internal Medicine Institute Of Clinical Medicine Universit
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Sugishita Yasuro
2nd Dept. Of Intern. Med. Faculty Of Med. Univ. Of Tokyo
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Sugishita Yasuro
Cardiovascular Division Department Of Internal Medicine And Department Of Gynecology And Obstetrics
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Sugishita Yasuro
Cardiovascular Division Department Of Internal Medicine Institute Of Clinical Medicine The Universit
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Kakihana Masaaki
Ibaraki Prefectural University of Health Sciences, Ami
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Ohtsuka Sadanori
Cardiovascular Medicine Institute Of Clinical Medicine Graduate School Of Comprehensive Human Scienc
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Ohtsuka Sadanori
Departments Of Cardiology Institute Of Clinical Medicine University Of Tsukuba
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Sugishita Yasuro
Departments Of Cardiology Institute Of Clinical Medicine University Of Tsukuba
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Kakihana Masaaki
Ibaraki Prefectural University Of Health Sciences
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Ohtsuka Sadanori
Department Of Internal Medicine The University Of Tsukuba
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Kazama Masahiro
Institute Of Clinical Medicine University Of Tsukuba
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Sugishita Yasuro
Clinical Medicine
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Sugishita Yasuro
The Department Of Internal Medicine Univeersity Of Tsukuba
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Otsuka Sadanori
Institute Of Clical Medicine University Of Tsukuba
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Sugishita Yasuro
Cardiovascular Division Department Of Internal Medicine University Of Tsukuba
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Sugishita Yasuro
Cardiovascular Division Department Of Internal Medicine Institute Of Clinical Medicine The Universit
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Kakihana Masaaki
Department Of Medicine Institute Of Clinical Medicine University Of Tsukuba
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Watanabe Hideki
Departement Of Cardiology Kinu Medical Association Hospital
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Kakihana Masaaki
2nd Dept. Of Internal Medicine Fac. Of Medicine Univ. Of Tokyo.
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Sugishita Yasuro
Cardiovascular Division Department Of Medicine Institute Of Clinical Medicine The University Of Tsuk
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Sugishita Yasuro
Department Of Internal Medicine University Of Tsukuba
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Sugishita Yasuro
Cardiovascular Division. Department Of Internal Medicine Institute Of Clinical Medicine. The Univers
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