Effect of Intravenous Amiodarone on Electrophysiologic Variables and on the Modes of Termination of Atrioventricular Reciprocating Tachycardia in Wolff-Parkinson-White Syndrome
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概要
- 論文の詳細を見る
Atrioventricular reciprocating tachycardia(AVRT) associated with the Wolff-Parkinson-White(WPW) syndrome, sometimes terminates spontaneously, generally sustains and eventually becomes drug resistant. Amiodarone is a potent antiarrhythmic drug that is sometimes effective in patients with AVRT which is resistant to conventional antiarrhythmic drugs. However, systematic studies concerning the effects of amiodarone on AVRT have not been reported. This study evaluated the effects of intravenous amiodarone on electrophysiologic variables, and on the sites and the modes of termination of AVRT. Fifteen WPW patients were studied. Nine had overt, and 6 had concealed WPW syndrome. Measurements of electrophysiologic variables and the induction of AVRT were performed by atrial and/or ventricular programmed stimulations. Amiodarone was then administered at a dose of 5 mg/kg over 5 min. The effective refractory periods(ERP) of the atrial, atrioventricular node, ventricular and accessory pathway were increased significantly by amiodarone. The conduction times of all the components were significantly lengthened by amiodarone, except for the His-ventricular(HV) interval in concealed WPW patients. AVRT was induced in all patients, and was terminated by amiodarone in 12 of 13 patients with sustained AVRT. After amiodarone, AVRT was induced in 9 patients. Spontaneous termination was observed 11 times in 3 of the 9 patients in whom AVRT was still induced. In these cases, the modes and sites of termination were the same as during the baseline state. The ERPs and conduction times of all components of AVRT, except the HV interval, were significantly lengthened by amiodarone. Amiodarone is efficacious for terminating AVRT wherever weak links exist. However, sites of spontaneous termination are not significantly affected by amiodarone.
- 社団法人日本循環器学会の論文
- 1999-02-20
著者
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Yamaguchi Iwao
Departments of Internal Medicine, Surgery, Pharmacology, University of Tsukuba
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Komaki Kohtaroh
Division Of Cardiology Gunma Prefectural Cardiovascular Center
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Kuga Keisuke
Department Of Cardiology
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Kuga Keisuke
Cardiology Department Of Internal Medicine University Of Tsukuba Graduate School Of Comprehensive Hu
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Sugishita Yasuro
Tsukuba Memorial Hospital
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Kajinami Koji
Department of Cardiology Kanazawa Medical University
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Yamaguchi Iwao
Division Of Cardiology Institute Of Clinical Medicine Graduate School Of Comprehensive Human Science
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Sugishita Yasuro
Department Of Medicine Tsukuba Memorial Hospital
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Sugishita Yasuro
Department Of Medicine Tsukuba University.
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Sugishita Yasuro
The Cardiovascular Division Department Of Internal Medicine Institute Of Clinical Medicine Universit
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Sugishita Yasuro
2nd Dept. Of Intern. Med. Faculty Of Med. Univ. Of Tokyo
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Sugishita Yasuro
Cardiovascular Division Department Of Internal Medicine And Department Of Gynecology And Obstetrics
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Sugishita Yasuro
Cardiovascular Division Department Of Internal Medicine Institute Of Clinical Medicine The Universit
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Sugishita Yasuro
Departments Of Cardiology Institute Of Clinical Medicine University Of Tsukuba
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Sugishita Yasuro
Clinical Medicine
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Sugishita Yasuro
The Department Of Internal Medicine Univeersity Of Tsukuba
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Sugishita Yasuro
Cardiovascular Division Department Of Medicine Institute Of Clinical Medicine The University Of Tsuk
-
Yamaguchi Iwao
Department Of Cardiology
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Kuga Keisuke
Department Of Internal Medicine University Of Tsukuba
-
Sugishita Yasuro
Cardiovascular Division Department Of Internal Medicine University Of Tsukuba
-
Sugishita Yasuro
Cardiovascular Division Department Of Internal Medicine Institute Of Clinical Medicine The Universit
-
Sugishita Yasuro
Cardiovascular Division Department Of Medicine Institute Of Clinical Medicine The University Of Tsuk
-
Sugishita Yasuro
Department Of Internal Medicine University Of Tsukuba
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Sugishita Yasuro
筑波大学 循環器内科
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Sugishita Yasuro
Department Of Medicine Institute Of Clinical Medicine University Of Tsukuba
-
Sugishita Yasuro
Cardiovascular Division. Department Of Internal Medicine Institute Of Clinical Medicine. The Univers
-
Sugishita Yasuro
Cardiovascular Division Department Of Internal Medicine Institute Of Clinical Medicine The Universit
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Yamaguchi Iwao
Department of Applied Chemistry, Faculty of Engineering, Osaka University
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