Decreased Heart Rate Variability in Patients With Diabetes Mellitus and Ischemic Heart Disease

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概要

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• We investigated the characteristics of decreased heart rate variability (HRV) in diabetic patients with ischemic heart disease (IHD). Twenty-one healthy control subjects, 17 diabetic patients without IHD, and 33 diabetic patients with IHD were studied. The diabetic patients with IHD were subdivided into 2 groups according to the severity of their IHD: severe or mild. HRV was evaluated in all subjects using the spectral variables of the all-frequency, lowrequency, high-frequency (AF, LF, HF) components and the LF/HF ratio were determined from Holter recordings. The AF and LF components in patients with diabetes only or diabetes and severe IHD were significantly lower than in control group, but the HF component was significantly lower only in the group of patients with diabetes and severe IHD. The LF/HF ratio did not differ significantly among the 4 groups, but was the lowest in diabetic patients without IHD. Patients with diabetes and mild IHD showed a slight decrease in HRV, but this was not significant. With regard to the circadian rhythm of HRV, the AF and LF components in patients with diabetes-only or diabetes and severe IHD were significantly decreased and showed the same pattern throughout the day. However, the HF component was decreased during more time zones in patients with diabetes and severe IHD, whereas the LF/HF ratio was lower during more time zones in the diabetes-only group. All spectral variables showed a tendency to be inversely related to the duration of diabetes in all diabetic patients. In particular, the LF/HF ratio showed a significant negative correlation. The HRV of diabetic patients was characterized by a decreased LF/HF ratio. It was concluded that, although HRV in diabetic patients with severe IHD was reduced mainly as a result of diabetic neuropathy, this was also partly due to a decline in parasympathetic tone as a result of myocardial injury.

• 社団法人日本循環器学会の論文
• 1996-11-20

著者

• Hamada Toshihiro

  Nippon Medical School

• Yoshida Akio

  Tokyo Medical University

• Sasaki Norihito

  Division Of Regenerative Medicine And Therapeutics Institute Of Regenerative Medicine And Biofunctio

• Fujimoto Yukihiro

  First Department Of Internal Medicine Tottori University

• Tanaka Yasushi

  Department Of Cardiovascular Medicine Tottori University Hospital

• Shigemasa Chiaki

  First Department of Internal Medicine, Tottori University

• Hoshio Akira

  First Department of Internal Medicine, Tottori University

• Mashiba Hiroto

  Kure Kyosai Hospital

• Tanaka Yasushi

  First Department of Internal Medicine, Tottori University

• Sasaki Norihito

  First Division, Department of Internal Medicine, Tottori University

• Fukuki Masaharu

  First Division, Department of Internal Medicine, Tottori University

• Mashiba Hiroto

  First Division, Department of Internal Medicine, Tottori University

• Hamada Toshihiro

  First Department of Medicine, Division of Cardiology, Tottori University Faculty of Medicine

• YOSHIDA Akio

  First Department of Internal Medicine, Tottori University Faculty of Medicine

• Haruyama Toshiaki

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• Fukuki Masaharu

  The First Department Of Internal Medicine Faculty Of Medicine Tottori University

• Fukui Masaharu

  The First Department Of Internal Madicine Tottori University

• Hoshio Akira

  First Department Of Internal Medicine Tottori University

• Hoshio Akira

  The First Department Of Internal Medicine Tottori University School Of Medicine

• Hoshio Akira

  First Department Of Internal Medicine Tottori University School Of Medicine

• Mashiba Hiroto

  First Department Of Medicine Faculty Of Medicine Khushu University

• Fujimoto Yukihiro

  The First Department Of Medicine Tottori University School Of Medicine

• Fujimoto Yukihiro

  First Department Of Internal Medicine Faculty Of Medicine Tottori University

• Akaiwa Yasuhisa

  Cerebrovascular Division Department Of Medicine National Cardiovascular Center

• MASHIBA Hiroto

  First Department of Internal Medicine and Research Institute for Angiocardiology, Faculty of Medicine, Kyushu University

• FUKUKI Masaharu

  First Department of Internal Medicine, Tottori University School of Medicine

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