[SHORT REPORTS]Phorbol Ester-Induced Excitation and Facilitation of the Heat Response of Testicular Polymodal Receptors in vitro

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Bradykinin and histamine excite polymodal receptors or facilitate their heat responses through the B_2 and H_1 receptors, respectively, which are reported to induce activation of protein kinase C in cultured cells. In order to clarifly possible involvement of protein kinase C activation in polymodal receptor activities, we studied the effects of phorbol esters, which stimulate protein kinase C, on polymodal receptor activities in vitro using canine testis-spermatic nerve preparations. Phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu)(10^-7,10^-6M) occasionally induced increases in the discharge rate. The heat response was facilitated by pretreatmnent of PMA and PDBu at 10^-7 M for 5 min. These results suggest that protein kinase C activation is involved in polymodal recepter activaties.
名古屋大学の論文