Reexamination of the Difference in Susceptibility to Adjuvant-Induced Arthritis among LEW/Crj, Slc/Wistar/ST and Slc/SD Rats
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概要
- 論文の詳細を見る
The present investigations were performed to assess the differences among rat colonies commonly used for neurophysiological research regarding the development of complete Freund’s adjuvant (CFA)-induced arthritis. Inflammatory signs including edema in the paw fluctuated remarkably among individual Wistar (Slc/Wistar/ST) and Sprague-Dawley (Slc/SD) rats, while the inflammatory signs of Lewis (LEW/Crj) rats appeared earlier and was severer and more consistent than Slc/Wistar/ST and Slc/SD rats. Edema in the hind paw developed in 100% of LEW/Crj rats with the lowest dose of CFA (0.6 mg/rat) used as compared with 64% of Slc/Wistar/ST (CFA 1 mg/rat) and 38% of Slc/SD rats (CFA 1.2 mg/rat). Retardation of weight gain was observed in Slc/Wistar/ST and Slc/SD rats in contrast to a severe weight decrease in inflamed LEW/Crj rats after the development of arthritis.
- 社団法人 日本実験動物学会の論文
著者
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Banik Ratan
名古屋大学環境医学研究所
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Banik R
Nagoya Univ. Nagoya Jpn
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Banik Ratan
Department Of Neural Regulation Research Institute Of Environmental Medicine Nagoya University
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Kasai Masanori
鹿児島大学・理・生命化学
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MIZUMURA Kazue
Department of Neural Regulation, Research Institute of Environmental Medicine, Nagoya University
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KASAI Masanori
Department of Neural Regulation, Research Institute of Environmental Medicine, Nagoya University
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Kasai M
Department Of Neural Regulation Research Institute Of Environmental Medicine Nagoya University
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Kasai Masanori
Department Of Chemistry And Bioscience Faculty Of Science Kagoshima University
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Mizumura K
Department Of Neuroscience Ii Research Institute Of Environmental Medicine Nagoya University
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Mizumura Kazue
Department Of Neural Regulation Division Of Regulation Of Organ Function Research Institute Of Envir
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