マウスの乳腺発育および関連形質に対する紅景天 (Rhodiola sachalinensis A.Bor.) の影響

概要

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The effects of Hong-jing-tian (HJT : Rhodiola sachalinensis A. Bor.) on mammary gland and related parameters were examined in SHN mice developing spontaneous mammary tumours. Free access to water-extract of HJT as drinking water (0.5 %) for 12 days resulted in the suppression of the growth of precancerous mammary hyperplastic alveolar nodules, the mammary tumour expression of transforming growth factor α mRNA and an increased necrosis of tumour cells, which was associated with the elevation of blood glutamic-oxaloacetic transaminase level. These would cause the partial inhibition by HJT of mammary tumour growth observed in this study. HJT treatment decreased urea nitrogen level in the circulation. Furthermore, the blood cholesterol level declined and the free fatty acid level was increased by HJT. These suggest that HJT can normalize or stimulate the kidney function and fat metabolism and these systemic effects of HJT may also contribute to its inhibition of the growth of mammary tumours and of uterine adenomyosis, which was also found in this study.
和漢医薬学会の論文
1999-04-30