Low-Energy Diet in Atopic Dermatitis Patients : Clinical Findings and DNA Damage

スポンサーリンク

概要

• 論文の詳細を見る

• Undernutrition without malnutrition(low-energy diet)increases maximum longevity, reduces the incidence of several cancers and delays their onset, in animal studies. It has also been demonstrated by experimental study that caloric restriction provides a beneficial effect on various inflammatory diseases. In this study, we offered a low-energy diet to patients with atopic dermatitis(AD). Nineteen adult patients(5 males and 14 females aged 15 to 36 years)were enrolled in the study which lasted 8 weeks. The energy intake was 55% of nutritional requirements;protein was 75%, calcium 180%, iron 130%, vitamin A 105%, vitamin C 250% and vitamin E 110% of the daily requirement. No patient experienced adverse reaction, and none dropped out of the trial. Body weight, body mass index(BMI), and systolic blood pressure had decreased significantly by the end of study. The SCORAD(scoring atopic dermatitis)index, which combines objective(extent and intensity of lesions)and subjective(daytime pruritus and sleep loss)criteria, was reduced significantly. In 11 patients with severe AD, there was a significant reduction in oxidative DNA damage. The change in the inflammatory intensity score and the change in BMI coused by energy restriction showed a significant positive correlation. The change in oxidative DNA damage levels and the change in BMI showed a positive correlation. These results clarify the relationship between weight loss and the improvement of AD. It may be hypothesized that this low-energy diet which included several additional nutrients has a possibility to reduce inflammatory symptoms of patients with AD.

• 日本生理人類学会の論文

著者

• NAKAMURA Harunobu

  Department of Public Health, Hamamatsu University School of Medicine

• Kouda Katsuyasu

  Department of Hygiene, Kansai Medical University

• Aoki T

  Department Of Biochemical Science And Technology Faculty Of Agriculture Kagoshima University

• TAKIGAWA Masahiro

  Department of Dermatology, Hamamatsu University School of Medicine

• TAKEUCHI Hiroichi

  Department of Public Health, Hamamatsu University School of Medicine

• Tanaka Toshiro

  Third Department Of Internal Medicine School Of Medicine Osaka University

• Kouda Mitsuo

  Kouda Clinic

• Takeuchi Akira

  Research and Development Center, Sunstar Inc.

• Tanaka Toshio

  Third Department of Internal Medicine, School of Medicine, Osaka University

• Kouda Mitsuo

  Research Institute for Microbial Diseases, Osaka University

• Takahashi Masaaki

  Department Of Orthopedic Surgery Hamamatsu University School Of Medicine

• Kouda Katsuyasu

  Department Of Hygiene Kansai Medical University

• Takeuchi Hiroichi

  Department Of Public Health Hamamatsu University School Of Medicine

• Takeuchi A

  Department Of Biological Science Faculty Of Science Nara Women's University

• Nakamura Harunobu

  Department Of Health Promotion And Education Graduate School Of Human Development And Environment

• Takigawa Masahiro

  Department Of Dermatology Hamamatsu University School Of Medicine

• Kotani Mayumi

  Kouda Clinic

• 竹内 章

  Tohoku Univ. Sendai Jpn

関連論文

• 2-21 The Research Report on Expansion of Research Bases of the Physiological Anthropology in Overseas(Proceedings of the 51st Meeting of Japan Society of Physiological Anthropology)
• Interrelationships among Whole-Body Coordination, Functional Potentiality, and Environmental Adaptability
• Beneficial Effects of Mild Stress (Hormetic Effects) : Dietary Restriction and Health
• Effects of Vegetable Containing Gamma-Aminobutyric Acid on the Cardiac Autonomic Nervous System in Healthy Young People
• A Novel Type of Milk Calcium Has Higher Calcium Bioavailability Compared with the Hydroxyapatite Type of Milk Calcium
• Milk Basic Protein Promotes Bone Formation and Suppresses Bone Resorption in Healthy Adult Men
• Bioavailability of Milk Micellar Calcium Phosphate-Phosphopeptide Complex in Rats
• High Strength Ni-Fe-W and Ni-Fe-W-P Alloys Produced by Electrodeposition
• Phylogenetic Position of a Deep-Sea Ascidian, Megalodicopia hians, Inferred from the Molecular Data
• Geological and microbial anomalies in the extinct submarine volcano, Shiribeshi Seamount, in the eastern margin of the Japan Sea
• Morphological Studies on the Bathyal Ascidian, Megalodicopia hians Oka 1918 (Octacnemidae, Phlebobranchia), with Remarks on Feeding and Tunic Morphology
• 金属ガラスおよびアモルファス合金の形成能の熱力学的評価
• Evaluation of Sialyl Lewis^x Antigen in the Skin and the Sera of Patients with Psoriasis Vulgaris
• Hepatic Function and Fasting : Animal Study by ^Tc-GSA Method(60th Anniversary Memorial Hall in Musashino Women's University)
• Calorie Restricted Diet and Urinary Pentosidine in Patients with Rheumatoid Arthritis
• Vegetarian Diet Ameliorates Symptoms of Atopic Dermatitis through Reduction of the Number of Peripheral Eosinophils and of PGE2 Synthesis by Monocytes
• Low-Energy Diet in Atopic Dermatitis Patients : Clinical Findings and DNA Damage
• Soluble form of vascular cell adhesion molecule-1 in systemic lupus erythematosus and discoid lupus erythematosus
• Thermal Stability and Magnetic Properties of Fe-Nd-Al Amorphous Alloys
• Classification of Bulk Metallic Glasses by Atomic Size Difference, Heat of Mixing and Period of Constituent Elements and Its Application to Characterization of the Main Alloying Element
• バルク金属ガラス生成要因の熱力学的解析と計算機支援による合金開発 (特集 金属ガラス--新材料としての最近の展開(上))
• Amorphous Co-Ni-P Alloys with High Saturation Magnetization Produced by Electrodeposition
• Effect of Sodium Hypophosphite on the Structure and Properties of Electrodeposited Ni-W-P Alloys
• Calculations of Crystallization Temperature of Multicomponent Metallic Glasses
• Amorphous Nd-Fe-Si Thick Ribbons and Their Hard Magnetic Properties
• New Fe-Co-Ni-Zr-B Amorphous Alloys with Wide Supercooled Liquid Regions and Good Soft Magnetic Properties
• Hard Magnetic Properties of Bulk Amorphous Alloys(Nano-materials)
• Thermal Stability and Magnetic Properties of Bulk Amorphous Fe-Al-Ga-P-C-B-Si Alloys
• Preparation of Bulk Pr-Fe-Al Amorphous Alloys and Characterization of Their Hard Magnetic Properties
• Hard Magnetic Bulk Amorphous Nd-Fe-Al Alloys of 12 mm in Diameter Made by Suction Casting
• Bulk Nd-Fe-Al Amorphous Alloys with Hard Magnetic Properties
• Acne Fulminans Coexisting with Pyoderma Gangrenosum-like Eruptions and Posterior Scleritis
• Trends in Body Mass Index, Blood Pressure, and Serum Lipids in Japanese Children: Iwata Population-Based Annual Screening (1993–2008)
• Roxithromycin inhibits chemokine-induced chemotaxis of Th1 and Th2 cells but regulatory T cells
• Efficacy and safety of preprandial versus postprandial administration of low-dose cyclosporin microemulsion (Neoral) in patients with psoriasis vulgaris
• Cutaneous Type of Adult T Cell Leukemia/Lymphoma : A New Entity among Cutaneous Lymphomas
• Alterations of immune functions in barrier disrupted skin by UVB irradiation
• Lupus Erythematosus Associated with C1 Inhibitor Deficiency
• Dominant expression of CXCR3 is associated with induced expression of IP-10 at hapten-challenged sites of murine contact hypersensitivity : a possible role for interferon-γ-producing CD8^+ T cells in IP-10 expression
• Unique therapeutic effects of the Japanese-Chinese herbal medicine, Sairei-to, on Th1/Th2 cytokines balance of the autoimmunity of MRL/lpr mice
• Acute Infectious Urticaria : Clinical and Laboratory Analysis in Nineteen Patients
• Lymphocyte stimulation test with drug-photomodified cells in patients with quinolone photosensitivity
• Roxithromycin down-modulates antigen-presenting and interleukin-1β-producing abilities of murine Langerhans cells
• Membranous and Soluble Forms of Fas Antigen in Cutaneous Lupus Erythematosus
• Systemic Administration of Hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang), a Japanese-Chinese Herbal Medicine, Maintains Interferon-γ Production by Peripheral Blood Mononuclear Cells in Patients with Mycosis Fungoides
• Evaluation of Soluble Cell Adhesion Molecules in Atopic Dermatitis
• Selective Expansions of T cells Expressing Vβ8 and Vβ13 in Skin Lesions of Patients with Chronic Cutaneous Lupus Erythematosus
• The Macrolide Antibiotic, Roxithromycin Suppresses IFN-γ-Mediated Immunological Functions of Cultured Normal Human Keratinocytes
• Metabolic Response to Short-Term 4-Day Energy Restriction in a Controlled Study
• 1-10 Dietary Restriction : Effects of Repeated Short-term Fasting on Allergic Inflammation(Proceedings of the 51st Meeting of Japan Society of Physiological Anthropology)
• Trends in Levels of Cholesterol in Japanese Children from 1993 through 2001
• An Adult with Atopic Dermatitis and Repeated Short-term Fasting
• The role of low-density lipoprotein receptors in sensitivity to killing by Photofrin-mediated photodynamic therapy in cultured human tumor cell lines
• Technetium-99m-GSA clearance in mice under long-term dietary restriction
• PD3-7 Acute Phase Effect on Cardiovascular and Autonomic Nervous Systems by Vegetable Juice Intake(Proceedings of The 8th International Congress of Physiological Anthropology)
• 1-10 Changes of EEG and Heart Rate Variability after Vegetable Juice Intake
• Developments and Applications of Bulk Glassy Alloys in Late Transition Metal Base System
• Formation and Functional Properties of Fe-Based Bulk Glassy Alloys
• Validation of curve-fitting method for blood retention of ^Tc-GAS: Comparison with blood sampling method
• E- and P-cadherin expression in tumor tissues and soluble E-cadherin levels in sera of patients with skin cancer
• S-3 The Concept of Functional Potentiality(Proceedings of the 50th Meeting of Japan Society of Physiological Anthropology)
• Lupus Erythematosus Profundus with Unusual Skin Manifestation : Subcutaneous Nodules Coexisting with Eyelid Plaques
• Photohapten TCSA painting plus UVA irradiation of murine skin augments the expression of MHC class II molecules and CD86 on Langerhans cells
• Eat Education and Growth : Intervention Study on Childhood(60th Anniversary Memorial Hall in Musashino Women's University)
• Allergic Dermatitis and Fasting : Animal Study by 8-OHdG(60th Anniversary Memorial Hall in Musashino Women's University)
• Cardiovascular Risk Factors in a Tourist Town : Association with Job-related Factors
• Disciplinary Approach and Protective Approach in School Health(Report No.1) (Selected Papers from 47th Annual Meeting of JASH at Fukuoka)
• Reduced Oxidative DNA Damage by Vegetable Juice Intake : A Controlled Trial
• Preparation and Mechanical Properties of Zr-based Bulk Nanocrystalline Alloys Containing Compound and Amorphous Phases
• Age constraint on the obuduction of ophiolitic rocks in the Yap Island,Philippine Sea,using nannofossils
• The current status and future direction of percutaneous peptide immunization against melanoma
• Relationship between Glycoxidation and Cytokines in the Vitreous of Eyes with Diabetic Retinopathy
• Suppresive Effects on Hypersensitivity by Dietary Resiriction in Isocyanate Sensitized Mice (Proceedings of the 54th Meeting of Japan Society of Physiological Anthropology)
• Effects of Dietary Restriction on Physical Performance in Mice
• Taste Development from Health Education among Schoolchildren : A Two-Year Intervention Study
• Trends in Body Mass Index, Blood Pressure, and Serum Lipids in Japanese Children : Iwata Population-Based Annual Screening (1993-2008)
• A Zero-Voltage-Switching Controlled High-Power-Factor Converter with Energy Storage on Secondary Side
• Development of Yap Islands and Tectonics of the Philippine Sea Plate at Its Southern Tip
• A Single-Ended Boost-Type High-Power-Factor Converter Using a Two-Input-Winding Transformer
• 日本の小児における身長と血圧との関連
• Histamine and Cutaneous Allergy : Old Friend, New Player
• Preparation and Characterization of Micellar Calcium Phosphate-Casein Phosphopeptide Complex
• Effect of Recovery From Obesity on Cardiovascular Risk Factors Among Japanese Schoolchildren : The Iwata Population-Based Follow-Up Study
• Height-Specific Serum Cholesterol Levels in Pubertal Children : Data From Population-Based Japanese School Screening
• Cut-off Values of Body Mass Index, Waist Circumference, and Waist-to-Height Ratio to Identify Excess Abdominal Fat : Population-Based Screening of Japanese Schoolchildren
• Effects of Modern Eating Patterns on the Cardiac Autonomic Nervous System in Young Japanese Males
• Association of Rapid Weight Gain During Early Childhood With Cardiovascular Risk Factors in Japanese Adolescents
• Relationship Between Body Mass Index at Age 3 Years and Body Composition at Age 11 Years Among Japanese Children : The Shizuoka Population-Based Study
• Increased Ratio of Trunk to Appendicular Fat and Increased Blood Pressure : Study of a General Population of Hamamatsu Children

もっと見る 閉じる

スポンサーリンク