Application of H2 Control for Evaluating the Ion Channel Gating on Excitable Cellular Membranes

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概要

• 論文の詳細を見る

• We introduced the H2 control principle to evaluate the Calcium ion channel gating function by Allosteric modeling. Calcium ion selective channel was described by four identical subunits. The modeling was characterized by cooperative positional changes of voltage sensitive S4 molecule in each of the subunit and concerted conformational changes of all the subunits. We applied the H2 control strategy for minimizing the influence of noise on the out put as the functions of the Calcium channel. The temporal changes in amounts of any given conformation of the Calcium channel were computed with altering the weighting parameters of the control inputs, the state variables and the control inputs on the controlled out put z. As a result, the S4 molecules in each subunit of the Calcium channel seems to influence the disturbance of the temporal changes in amounts of the specific conformation of Calcium channel system.

• 一般社団法人日本機械学会の論文

著者

• SUGIURA T.

  Department of Surgery, Chiba University School of Medicine

• OKITA Y.

  Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine

• Okita Y

  Department Of Engineering. Shizuoka University

• Hirayama H.

  Department of Public Health Asahikawa medical college

• Okita Y.

  Department Of Gastrointestinal And Pediatric Surgery Mie University Graduate School Of Medicine

• Okita Y.

  Department of Engineering. Shizuoka university

• Sugiura T.

  Department of Engineering. Shizuoka university

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