螢光抗体法による結核死菌感作動物における抗体保有細胞の研究

概要

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Antibody-holding cells against antigens of tubercle bacilli of guinea pigs sensitized with heat-killed tubercle bacilli were investigated by fluorescent antibody technique. 1) Large and small mononuclear cells in the peritoneal exudate of sensitized guinea pigs reacted on antigens of tubercle bacilli and were well stained specifically. 2) Lymphocytes and plasma cells in lymphnodes and spleen of sensitized guinea pigs were specifically by fluorescent antibody technique. 3) Cells in liver, kidney, adrenal, thyroid and salivary glands were not stained specificially by fluo-rescent antibody technique. 4) Eosinophilic leucocytes in the peritoneal exudate, lymphnodes and spleen were stained rather markedly, but it was considered to be non-specific as compared with controls. The above results suggested that, by the sensitization with tubercle bacilli, intraperitoneal mono-nuclear cells, lymphocytes and plasma cells in lymphnodes and spleens of sensitized guinea pigs came to hold specific antibodies against antigens of tubercle bacilli. It was discussed that these antibodies might take part either in immediate type- or in delayed type-hypersensitivity of tuberculosis.
日本アレルギー学会の論文
1966-03-30