気管支喘息における間接的好塩基球脱顆粒試験の検討
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Shelley and his colaborators reported that the blood basophil cell undergoes degranulation durnig the antigen-antibody reaction, and that this basophil degranulation may be used as a indicator of allergic sensitivity which parallels intensity with specific circulating antibody in any allergic state. The author attempted to confirm their observation by studying basophil degranulation induced by adding the antigens to the sera of the patients and guinea pigs known to be sensitive to "Maiko" and to the sera of the house dust sensitive subjects. The author employed the indirect tehcnique described by Shelley in 1962, in which basophils obtained from the buffy coat of rabbit blood are placed on slides prestained with neutral red, and sera from sensitive guinea pigs or human subjects are added to it, and then challenged with specific antigen. The criteria of the positive test was the same as described by Shelley. 1) Indirect basophil degranulation test, using as the antigen 40% and 60% saturated ammonium sulphate precipitated fraction from "Makio" extract, proved positive in the majority of the persons exposed to "Maiko", and proved negative in the majority of the persons without exposure to "Maiko". 2. When the author used house dust extract as antigen, this test proved positive in the most of the house dust sensitive patients, but negative in the house dust non-sensitive men. 3) On the guinea pigs actively sensitized with "Maiko" and not provocated, the test using "Maiko" antigen, proved positive in all cases, however after provocated inhalation with "Maiko", the most cases become negative, and the majority of the non-sensitized control animals proved negative. The author concluded that the test seems to be specific and useful means to detect the hypersensitive state.
- 日本アレルギー学会の論文
- 1967-05-30
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