胆嚢炎発生に関する免疫学的研究 : 特に組織学的所見を中心として

概要

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Matsukura has been pointed out that allergic reaction in gall-bladder by the components of E. coli may have a significant role in producing cholecystitis. The authors carried out the experimental studics on cholecystitis with guinea pigs and rabbits in vitro and in vivo and also histological examinations on the isolated gall-bladder and liver were also carried out. The results obtained were as follows: 1) Anaphylactic contracation of isolated gall-bladder was tested by the modified Magnus technique. By the addition of whole antigen of Ecoil, the isolated gall-bladder of normal guinea pig did not contract but that of guinea pig passively sensitized with anti-E. coli rabbit serum showed a remarkable contraction and the desensitization phenomenon by the addition of the same antigen was also demonstrated. 2) No gross inflammatory reaction was observed in control normal rabbits injected E. coli via portal vein, however, high grade of inflamatory reaction was observed in the rabbits previously immunized with whole components of E. coli. 3) Histological findings of gall-bladder and liver in the experimental cholecystitis in rabbits by the antigen-antibody reaction of E. coli seems to be similar to the histological findings of gall-bladder and liver extracted from the patients of cholelithiasis and cholecystitis.
日本アレルギー学会の論文
1966-07-30