同一局所反復施行によるツベルクリン反応の推進に関する研究 : 第17報 促進反応の発現機序に関する研究 (IV)

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概要

• 論文の詳細を見る

• In 1960, the tuberculin active peptide (TAP yamamura) was prepared by Yamamura from cells of M. tuberculosis and proved by Someya to have no sensitizing effect, when injected into guinea pigs with adjuvant. In the present experiment, an attempt was made to test the influence of repeated TAP injections. 1) Old tuberculin and 0.25 mcg of TAP were injected respectively, at two sites on the backs of five adults. After one month old tuberculin and TAP were injected at four previously injected sites and at two new sites after the manner of the preceeding experiment with PPD and CF. Reactions were observed as previous reports. At all four sites where injection was repeated, early reaction and accelerated reaction were observed in contrast to the new sites. 2) Three adults were given TAP injection at the new site a the left upper arm, and also given tuberculin injetion at the new site on the right upper arm. Thereafter, every one to two months, TAP and tuberculin were injected at the same sites respectively. Injections were repeated three times. Reactions were observed 4, 24, 48 hours after injection. In the first test, no early reactions were observed on both sides, and intensity of reaction increased as time elapsed. In the second test on both sides remarkable erythema and induration appeared after four hours. The reaction attained their maximum intensity after 24 hours. In the third and fourth tests on both sides, the early reaction were nearly the same as in the second test, while the intensity of the delayed reaction after 24 to 48 hours decreased in accordance with the repetition of the injection. The reaction pattern against TAP was almost the same as against tuberculin. In summary, the injection of TAP also influenced the subsequent tuberculin reaction at the same site. Between old tuberculin and TAP no significant difference was observed in the effect of modifying the subsequent tuberculin reactions.

• 日本アレルギー学会の論文
• 1966-06-30

著者

• 宮下 晴夫

  群馬大学医学部小児科学教室

• 宮下 晴夫

  群馬大学小児科学教室

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