X線照射された動物の血清及び臓器の同種動物に対する抗原性についての実験的研究 : 第2編肝臓部X線照射ウサギ血清の同種抗原性について

概要

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The antigenicity was examined by the injection of serum of the rabbit pretreated by X-ray irradiation to the liver, according to the way described in the previous report. Production of complement-fixing antibody and leucolysing antibody in the serum were evidenced, although antibody titer was rather lower. Consequent distarbances of the liver function and allergic histological changes chiefly localized in the liver tissue were also noticed. In the blood of the rabbit, sensitized with the X-ray irradiated serum, we also demonstrated the complement-fixing antibody and the leucolysing antibody which is also reactive to the X-ray irradiated liver emulsion. Paper-electrophoretically, the site of peak concentration of the irradiated liver emulsion coincided well with that of the β-globulin fraction of thus treated serum. In summary, it is apparent that the X-ray irradiation to the liver induced the denaturation of the rabbit's own protein, especially at the time of protein synthesis in the liver, resulting in anomalous homologous antigenicity of the serum, further more, X-ray irradiation also apparently induced liberation of the denaturated liver tissue protein into the blood stream, which could combine to the above mentioned serum protein, presenting allergic changes selectively localized in the liver.
日本アレルギー学会の論文
1966-02-28