X線照射された動物の血清及び臓器の同種動物に対する抗原性についての実験的研究 : 第1編肝臓部X線照射ウサギ肝エムルジヨンの同種抗原性について

概要

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A series of the experiment was made, in which the possibility was studied whether organ or serum of the animal pretreated by X-ray irradiation in order to induce degenerative alteration of protein synthesis, could obtain the antigenicity to homologous animal without any addition of adjuvant. The emulsion was obtained from the liver which was pretreated by the intermittent X-ray irradiation under the dosis of 6, 000 r for twelve days. Nextly, rabbits were sensitized and reinjected by repeated intraperitoneal injections of supernatant of thus obtained emulsion. The complement-fixing antibody, the leucolysing antibody and some of the precipitable antibody were demonstrated in the serum 9 to 18 days after the sensitization. Although anaphylactic shock or Arthus' phenomenon failed to develop, decrease in serum albumin content occur and increase in γ-globulin content was observed consistently. Microscopically, most severe damage was observed in the liver tissue, contrasting to rather normal histological findings in the control groups treated either by injection of non-irradiated liver emulsion, or by sensitizing injection followed by no provocating procedure. In summary, thus obtained antigen did present consistent antigenicity to homologous animal and the response to the antigen appeared to be very much similar to the pathological picture of "auto-immunedisease".
日本アレルギー学会の論文
1966-02-28