X線照射された動物の血清及び臓器の同種動物に対する抗原性についての実験的研究 : 第3編 X線照射同種血清の抗原性についてErythron-Allergy を指標としての検討

概要

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The antigenicity of X-ray irradiated serum to the homologous animal was examined by use of the "erythron-allergy" phenomenon. The X-ray irradiated serum of rabbit as described in the Part II was added to the bovine erythrocyte cephalin. This mixture was used for sensitizing and provoking the "erythron-allergy." in the rabbit. Typical hypoplastic anemia was induced by the provoking injection, and these results were well coincided with those induced by the "erythron-allergy" using the heterologous protein as transporter. In contrast to these findings, non-irradiated serum or serum irradiated in vitro failed to show any findings similar to the above mentioned changes. Above results appear to be indicating that X-ray irradiation to the liver in rabbits did induce dear-rangement of the protein synthesis in the liver resulting in homologous antigenicity of the serum as evid-enced by the positive "erythron-allergy" when the serum was used in combination with the erythrocyte cephalin fraction. In summary, results of these 3 groups of experiments, have clearly indicated that effect of X-ray irradiation to the liver is so damaging as to cause denaturative alterations of somatic protein, which could operate as a homologous antigen and induce similar clinical findings to those of so called "auto-immune disease".
日本アレルギー学会の論文
1966-02-28