蕁麻疹の発現機序

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Recent studies show that allergic response do not cause directly by the antigen-antibody reaction but are mediated by the release of some chemical agent of endogenous origin. The best known of these, of course, is histamine but many workers have felt that there is room for other substances in the pathogenesis of many allergic symptoms. Histamine, acetylcholine, serotonin and kallikrein solution was injected intradermal and found the whealing response elicited by histamine behaved in all minute details and under all tested artificial conditions in exactly the same way as whealing responses elicited otherwise and occurring and natural conditions. Histamine liberator, compound ^<48>/_80, was injected intravenously to ten urticaria patients and caused the typical urticaria over the face and trunk. The minimam dose caused urticaria was 1500 μg aμd maximum 2500 μg. Dermographia elevata was done at tae thorax of urticaria patients and on the time, it was almost disappered (three hours later), dermographia elavata was done again to cross the former and was inhibited at the cross area. On an another patient who debelops the urticaria after taking salad oil, dermographie was done before talking and then taken it one hour later. Urticaria developed at the trunk except the area of dermographie. Strong stroke was done at the back of the rat skin and normal mast cell count at the site was connted before and after. After five minutes the mast cells decreased to sixteen per cent and after thirty minutes it recovered to fifty per cent. Recently mammalian mast cells haqe heve found to contain not only heparin but also histamine and now mast cells are recognized as an important source of histamine. The authorsadvocated the new mechanism of development of urticaria.
日本アレルギー学会の論文
1965-01-30

蕁麻疹の発現機序

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