肝臓アレルギーに関する研究 : 第2編肝自己抗体の生体内動態に関する臨床的検討

概要

論文の詳細を見る
An immunoserological study was carried out on anti-liver-autoantibody in vivo by means of electrophoresis and phase contrast microscopy of the liver-cells. 1. The anamestic reaction could be induced by the administration of ACE in significant number of cases in whom the anti-liver-autoantibody had been found in the circulating blood. 2. Active pathological changes were still noted in those cases of viral hepatitis or cirrhosis in whom the anti-liver-autoantibody had been found in the circulating blood and reappeared following the ACE injection. 3. It was suggested that some cases of chronic hepatitis and livercirrhosis showed a clinical finding which was considered to be a sensitized state with the liver-antigen, and in this cases the anti-liver-autoantibody was evidently thought to be an etiologic factor for these liver diseases. 4. When in vitro, the anti-liver-autoantibody acted on the liver cells of patients who had a positive titer of anti-liver-autoantibody in the blood, the liver cells manifested more promoted roughness of granular substance in protoplasm, and more increased electrophoretic mobilities than the negative cases of anti-liver-autoantibody titer in the circulating blood.
日本アレルギー学会の論文
1961-07-30