ウサギの実験的結核性肺空洞組織 : 磨砕上清液の補体吸着量の推移

概要

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Following the Yamamura's method, adult rabbits were sensitized with subcutaneous injections of tuberculous bacilli (Miwa strain) killed by boiling in water and suspended in Freund's adjuvant. Affer the sensitization, the rabbits received the secondary injection of the antigen, i.e., killed bacilli of the same strain, into their lungs. At various weeks after the injection, tissues of tuberculous lesions were homogenized and centrifuged, and the amount of adsorbed complement in the supernatant was determined. Adsorption of complement began to increase soon after the injection of the secondary antigen, the peak being reached at the end of the second weed. On the 4th week, a sudden decrease took place. If diluted solution of tuberculin was added to the supernatant in vitro, the amount of adsorbed complement was approximately two times larger than that in experiment without tuberculin, a marked increase occurring two weeks after the injetion. The antibody in the lesions seems to resemble in nature the incomplete antibody reported by Sindo et al. in the case of tuberculosis. Relationship between the antibody in tuberculous lesions and pathological changes in the lesions has been discussed.
日本アレルギー学会の論文
1961-06-30