モルモットの肺結核病巣形成におよぼす抗体移入の影響
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概要
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1. Male white gunea pigs, about 300 g in body weight, was given a single injection of 0.2 ml of serum of rabbits sensitized with dried tuberculous bacilli of the Aoyama B strain sterilized at 100℃, into the posterior lobe of the lung, the injection needle being inserted through a point between the right third and fourth ribs on the dorsal side of the body. Four hours later, the animals received an injection of the same heat-sterilized bacilli suspended in physiological saline solution. Pathological changes taking place in the lung were studied 24 hrs, 48 hrs, 3 weeks and 6 weeks after the treatment. Guinea pigs inoculated with the antigen only served as controls. Suspensions used were prepared by adding 10% liquid paraffin. 2. In animals received the passive transfer of antibodies, tuberculous lesions were rapidly developed in the lung and at 48 hours, the lesions occupied a greater part of the posterior lobe in 4 of 10 animals. At this time, difference in size of lesions between the antibody-antigen group and antigen control group was most marked. At 3 weeks, lesions were sometimes still larger in the former than in the latter, but at 6 weeks, difference in size of lesions was hardly discernible between the two groups of animals. 3. In antibody-antigen group, infiltration of polymorphonuclear leucocytes and proliferation of epithelioid cells were already obvious in developing lesions 24 hours after injections. At 48 hours, the epithelioid cell proliferation was decidedly more marked in this group than in the controls. However, the difference concerning the cell proliferation between the two groups was less marked at 3 weeks and no longer discernible at 6 weeks. 4. Both groups of animals reacted negatively to the Middlebrook-Dubos hemagglutination test and the Sindo-Middlebrook hemolytic test at 24 and 48 hours. At 3 and 6 weeks, both groups being statistically non-significant. 5. Tuberculous lesions developed in the lung following passive transfer of antibody were qualiitatively the same at tissue level as those formed under active immunization. The only difference between the two appeared to be more rapid progresses of changes in the formed than in the latter. 6. It seems likely that the antigen-antibody reaction is an important factor involved in the rapid development of tuberculous lesions in animals receiving passive transfer of antibodies.
- 日本アレルギー学会の論文
- 1967-12-30
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