8.痛みと凝固線溶とは関係があるか(第4回プラスマキニン研究会)

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Recently it has focused the attention of investigators that a certain kinds of polypeptides which were looked to provoke pain sensation, might take some common or similar pathways to be developed, to agents of blood coagulation or fibrinolysis, but their virtual and detailed mechanism was not cleared up yet. The authors tried to scrutinize the relationship between them, following up the shift of coagulation-fibrinolysis system in typical diseases or syndromes in which pain sensation could be invited relatively simple maniplations and particularly the correspondence of the activation of Hageman factor (Factor XII) with the enhancement of fibrinolysis. In a patient with Raynaud's syndrome who began to feel severe pain together with violet colouration at his left forearm shortly after it was braced tightly with a cuff at the pressure of 140 mmHg. Blood was drawn by venipuncture from cubital veins of both forearms before and at 5 minutes after the bracement, and the non-contact and contact partial thromboplastin times (PTT) aed euglobulin lysis time (eug LT) were measured to be found that the non-contact PTT was shorter at the braced side than the other, but the fibrinolytic activity measured by eug LT did not show any correspondence with this shift of Factor XII activity. At the same time, however, the Rumpel-Leede test for capillary fragility was proved to be higher positive at the braced side. This poor causal relationship between PTT and eug LT was also found in blood of many cases with Raynaud's disease or syndrome. Eisen proposed a schema for activation mechanism of plasmakinin and its allied materials in 1966, in which plasmin should play active role, and in our cases pain sensation and elevated capillary permeability were invited by the ischemic muscle contraction test, but the participation of fibrinolysis agents was not proved so eloquently. This interruption of causal relation between activation of fibrinolysis and enhancement of coagulation which was observed in blood of various cases, such as with thromboangitis obliterans (Buerger's disease), thrombophlebitis acuta, blood vessel trauma, etc. This discrepancy was further observed in vitro experiments in which contact factors were activated by contact with celite, kaolin, glass powder, etc., and was also supported by data of Suzuki et al. and Fujii et al. who applied the most purified agents sofar in their reaction systems.
日本アレルギー学会の論文
1970-08-30

8.痛みと凝固線溶とは関係があるか(第4回プラスマキニン研究会)

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